生物分子互作分析系统SPR420A ILVES

生物分子相互作用分析仪（多参数表面等离子体共振）最新样本2016

最新的技术样本在原来设备的技术参数基础上又有了新的更新，同时推出一款最新的产品型号SPR400，这一产品在传统的设备基础上能更好的实现您的技术要求！

使用多参数表面等离子体共振分析仪MP-SPR表征聚合物-层的吸附和厚度

使用多参数表面等离子体共振分析仪MP-SPR表征聚合物-层的吸附和厚度： Polymers are extensively studied and often interactions play a key role in the product functionality. Two separate polymer interaction studies were conducted using label-free real-time Multi-Parametric Surface Plasmon Resonance (MP-SPR). Functionalization of nanocellulose surfaces was performed by adsorption of block copolymers. The e?cacy of anti-fouling of the PEG-based polymer brushes was quanti?ed by measuring adsorption of serum samples. Based on the MP-SPR measurements, polymers were further characterized in terms of thickness and adsorbed mass. Nanocellulose functionalization was con?rmed to be successful and -OH terminated 10 kDa PEG was found to be the best anti-fouling coating, producing 99% resistance.

生物大分子分析系统MP-SPR测量药物和蛋白相互作用实验的重复性和再现性

生物大分子分析系统MP-SPR测量药物和蛋白相互作用实验的重复性和再现性： IgG dissociation kinetics from immobilized Protein A was studied using real-time Multi-Parametric Surface Plasmon Resonance (MP-SPR). Various dissociation bu?ers were tested to determine the most e?cient solution. A unique feature, PureKinetics?, allows di?erentiation of real binding from interfering bulk signal artifacts, providing a pure binding signal. The method can clear out even extremely large bulk signals, such as high-ionic strength dissociation bu?ers. In this study, the most e?cient dissociation from Protein A was achieved with bu?ers of pH below 4.0.

使用分子间相互作用分析仪MP-SPR在空气中以原子级分辨率表征石墨烯层

使用分子间相互作用分析仪MP-SPR在空气中以原子级分辨率表征石墨烯层： Chemical-vapour-deposition (CVD)-grown graphene films were characterized with non-invasive Multi-Parametric Surface Plasmon Resonance (MP-SPR). Both layer thickness and refractive index were obtained simultaneously from a single measurement without prior information on either of the parameters. After the first initial deposited layer, the layer thickness of the graphene monolayer was 0.37nm which is in good agreement with values from other methods. Refractive index and extinction coefficient of graphene layer on Al2O3 were 3.135 and 0.897 respectively at 670nm wavelength.

使用生物大分子相互作用仪MP-SPR研究病毒之间的相互作用

使用生物大分子相互作用仪MP-SPR研究病毒之间的相互作用：To develop cancer vaccines, a virus-peptide interaction was measured with Multi-Parametric Surface Plasmon Resonance (MP-SPR). Viruses were coated with peptides in order to increase virus immunogenicity. Oncolytic adenoviruses (OAds) were attached to the sensor surface. Tumor-specific major histocompatibility complex (MHC) peptides attachment to the OAds was measured in real-time. Modified positive polyK-SIINFEKL peptide bound to the virus surface (binding constant 2.88 x 10-6M), whereas unmodified neutral SIINFEKL peptide did not bind.

使用生物分子相互作用仪MP-SPR测量小分子量药物与蛋白之间的相互作用

使用生物分子相互作用仪MP-SPR测量小分子量药物与蛋白之间的相互作用:合成药物向生物药物转变的过程中产生了新的挑战，而MP-SPR独一无二的PureKinetics?特性和广泛的工作范围使其成为一项应对新挑战的必不可少的工具。从通过药物摄取路径进行抗体表征、药物控制释放策略、小分子测量、纳米颗粒靶向性直到活细胞的药物内在化，MP-SPR帮助您在竞争中取得领先。使药物在体内产生疗效。

同时使用分子相互作用仪MP-SPR、电位测定法和阻抗谱法实时监测抗体的结合

同时使用分子相互作用仪MP-SPR、电位测定法和阻抗谱法实时监测抗体的结合：抗体表征可以在各种液体，包括复杂液体，比如100%血清、尿液或唾液中进行抗体-抗原相互作用的亲和力和动力学测量。 Multi-Parametric Surface Plasmon Resonance (MP-SPR) equipped with an electrochemistry (EC) flow-cell was used to run potentiometric and impedance measurements in parallel with the MP-SPR measurement. The binding reaction of anti-methotrexate to immobilized small molecule weight drug methotrexate (MTX) was followed by MP-SPR and by potentiometry and Electrochemical Impedance Spectroscopy (EIS). Methotrexate binding produced a relatively large impedance response and antibody molecules a small response, whereas potentiometry values stayed equal during interactions. The strong binding of antibody molecules was observed in the MP-SPR response.

使用电化学生物大分子互作系统实时监测金属的剥离和沉积

使用电化学生物大分子互作系统实时监测金属的剥离和沉积：Real-Time Monitoring of Metal Stripping and Deposition with EC-MP-SPR Multi-Parametric Surface Plasmon Resonance (MP-SPR) enables combined electrochemical and SPR measurements (EC-MP-SPR). In this study, MP-SPR was utilized to follow real-time copper deposition and stripping processes under constant current (galvanostatic) conditions. Process of deposition of copper in terms of layer thickness (d), refractive index (n) and absorption coefficient (k) was determined with dedicated LayerSolver? software.

使用生物分子相互作用分析仪SPR 体外实时监测药物的释放动力学

使用生物分子相互作用分析仪SPR 体外实时监测药物的释放动力学。 制药领域：在合成药物向生物药物转变的过程中产生了新的挑战，而MP-SPR独一无二的PureKinetics?特性和广泛的工作范围使其成为一项应对新挑战的必不可少的工具。从通过药物摄取路径进行抗体表征、药物控制释放策略、小分子测量、纳米颗粒靶向性直到活细胞的药物内在化，MP-SPR帮助您在竞争中取得领先。使药物在体内产生疗效。“MP-SPR使我们能够从事活细胞单层的工作，而活细胞单层可直接或借助于，比如纤维连接蛋白和其他的生长促进蛋白在传感器表面生长。通过MP-SPR，借助纳米颗粒和其靶标的表面特性，我们能够观察和量化细胞摄取纳米颗粒的动力学的差异。

BioNavis生物分子相互作用分析仪应用领域再创新高度

BioNavis生物分子相互作用分析仪应用领域再创新高度，主要内容是有关BioNavis在生命科学、材料科学和传感器等领域的应用分析。

生物大分子相互作用分析仪SPR表征大面积的原子层石墨烯膜

用生物大分子相互作用分析仪SPR表征大面积的原子层石墨烯膜 SPR表征大面积的原子层石墨烯膜 详情请点击右上角：免费下载！ 生物大分子，分子间相互作用，表面等离子体共振，生物分子相互作用

AN # 140使用MP-SPR测量自组装金纳米粒子

Gold nanoparticles were immobilized on a monolayer self-assembled on gold. Functional groups on the chain ends of the monolayer facilitated an anchoring of gold nanoparticles to the layer. Multi-Parametric Surface Plasmon Resonance (MP-SPR) enabled a real-time measurement of the binding of the gold nanoparticles to the surface layer.

AN # 139使用MP-SPR表征脂质支持膜

Protein - antibody interactions are extremely important research area for pharmaceutical industry and protein research. Anti-body-based biotechnology drugs have been shown to be effective treatments to some obstinate diseases, like Bevacizumab for cancer therapy and Adalimumab for rheumatoid arthritis.

AN # 138使用MP-SPR测量抗体和抗原的相互作用

Introduction Protein - antibody interactions are extremely important research area for pharmaceutical industry and protein research. Anti-body-based biotechnology drugs have been shown to be effective treatments to some obstinate diseases, like Bevacizumab for cancer therapy and Adalimumab for rheumatoid arthritis.

AN#137使用MP-SPR测量药物与细胞单层的相互作用

Cell monolayer was deposited on a SPR sensor slide. Multi-Parametric Surface Plasmon Resonance (MP-SPR) was used to measure drugs (propranolol and D-mannitol) interaction with the cell monolayer in real time and in controlled flow conditions. It was possible to distinguish between paracellular and transcellular drug absorption routes.

AN#136使用MP-SPR监测聚合物坍塌和扩展

Cell monolayer was deposited on a SPR sensor slide. Multi-Parametric Surface Plasmon Resonance (MP-SPR) was used to measure drugs (propranolol and D-mannitol) interaction with the cell monolayer in real time and in controlled flow conditions. It was possible to distinguish between paracellular and transcellular drug absorption routes.

AN#135使用MP-SPR测量气体诱导的表面变化

MP-SPR instrument was used to characterize changes in a polymer film induced by different gases. Different humidities showed concentration dependent interaction with polymer and ethanol vapour seemed to penetrate to the polymer layer.

AN # 132通过MP-SPR测定功能层的结合能力

Clinical diagnostics is moving from centralized laboratories closer to the patient, into the doctor’s office, pharmacies, homes. The requirements for such point-of-care (POC) devices differ greatly from centralized laboratory demands. POC devices should provide low-cost and easy to use analytical tool for rapid analysis of analytes with clinical relevance. Many paper electronics opens up possibilities to do electronic platforms for cheap, disposable and recyclable applications that can be utilized in biosensing or medical diagnostic.

AN # 131使用MP-SPR技术的深扫描光学现象测定微米尺度层的光学特性和相互作用

Optical biosensor techniques based on evanescent field sensing, like surface plasmon resonance (SPR) have typically an effective detection depth of a hundred nanometers. For many coating-interaction studies coatings of this thickness can be difficult to achieve. Optical waveguides are phenomenon that can occur in structures able to capture and internally reflect light. A related optical phenomena, so-called SPR waveguide mode, might occur when between metal and the sample medium is a dielectric guiding layer with sufficiently high dielectric constant (ε) and thickness (d) (Fig. 1). The plasmon excitation by the visible light can be exited at several angles which are dependent on the whole optical system properties, and an angular spectrum of reflected light intensity (SPR-angular curve) will show several minima (Fig. 2).

AN#129生物分子间相互作用和靶向药物输送的流体力学效应的研究

Blood stream hydrodynamics is known to be an important pharmacokinetic factor that varies in different vessels and organs throughout the body. Liposomes are used in drug delivery systems to carry drug molecules to the effective site with some products already on the market. Liposomes are also widely studied as drug delivery systems for new drug targeting applica?tions. Multi Parametric Surface Plasmon Resonance (MP-SPR) is an in vitro label free method capable of providing information about interfacial adsorption events and molecular interaction kinetics. The SPR Navi 200 instrument′s open design allows easy custom?ization and control of the hydrodynamic conditions inside the measurement chamber. The Quartz Crystal Microbalance technique (QCM) senses the amount of water dynamically coupled to biomolecules, which is sometimes a useful additional information, but which can also be a complicating factor in assays. The difference in the hydrodynamic flow conditions for SPR and QCM