solariX XR傅里叶变换离子回旋共振质谱

GRIDD专访：基于片段的药物研发促进新药革新

专访：Sally-Ann Poulsen’s laboratory at the Griffith Institute for Drug Discovery (GRIDD) uses advanced MRMS technology to support their research in small molecule drug discovery. 位于澳大利亚昆士兰州的Griffith大学药物发现研究院GRIDD，拥有庞大的天然产物资源库，一个由澳大利亚各种植物、真菌和无脊椎动物的天然提取物构成的药物发现平台，其中包括10000个提取物库和50000个天然产物组分库，GRIDD的科学家将布鲁克solariX XR磁共振质谱仪用于基于片段药物筛选技术探寻隐藏的新药，实现了对药物研发快速分析、高效率和降低成本的要求，solariX XR的超高分辨率性能给蛋白质小分子复合物分析提供可靠高效的结果。

运用FTMS直接进样和多变量分析描绘橄榄油指纹图谱

In this study, LC free magnetic resonance mass spectrometry (MRMS) analysis was employed for mapping and quality control assessment of Greek extra virgin olive oil (EVOO) using a new and intuitive software workflow.

基于MALDI FTMS成像技术的癌变生物标记物N-聚糖的研究

In this application note, we describe a workflow for MALDI Mass Spectrometry Imaging (MSI) of proteins from a variety of FFPE tissues. The method comprises steps of paraffin removal and antigen retrieval followed by on-tissue digestion and deposition of MALDI matrix.

Characterization of petroleum samples via thermal analysis coupled to APCI FTMS

Thermal analysis coupled to ultra-high resolution mass spectrometry enables the detailed temperature resolved chemical characterization of the evolved gas mixtures on the molecular level. It can be used as complementary technique to direct infusion experiments or GC-APCI. Additional information is gained due to higher temperatures feasible with the thermo balance, e.g. pyrolysis fragments can give structural information about larger molecular entities. APCI is a sensitive technique for detecting the polar and medium-polar species released during the heating process. We have shown that TG-APCI FT-MS can be applied for various petroleum samples from different distillation ranges. Ultra-high resolution was needed to differentiate between the chemical species in the complex evolved mixture.

C&EN封面故事 - 质谱成像探秘药物在组织中的分布

Sometimes it's not enough to know how much drug has reached a particular tissue. Sometimes you need to know where in that tissue the drug has gone. To answer that and other questions, pharmaceutical companies are turning to imaging mass spectrometry. It allows pharma scientists to collect information about drug distribution much earlier in the discovery process than previously possible. The resulting pictures are helping drug developers prevent toxicity and off-target effects.

会议邀请--布鲁克FTMS用户交流研讨会

突破仪器性能的局限，挑战分析领域的极限，布鲁克用极限分辨率FTMS技术帮助科研工作者看到其它类型质谱所不能提供的“隐藏信息”，达到从结构到功能的转变。 布鲁克将携手中国广州分析测试中心（广东省测试分析研究所） 、广东省分析测试协会，于2017年12月1日-- 2日在广州举办2017年布鲁克FTMS用户交流研讨会，本次会议将邀请众多国内外专家呈现最新的具有针对性和广泛性的研究实例。我们诚邀您参加本次会议。 会议日期：2017年12月1日-12月2日 会议地点：广州市越秀区先烈中路100号大院34号楼7楼会议室 报告单位 ：（排名不分先后，如有调整，以后续通知为准。）