DNASwift SAX-1S 寡核苷酸柱
将一根强阴离子交换柱与可提供超高分辨率的 Thermo Scientific™ DNASwift™ SAX-1S 寡核苷酸柱联合使用，可对寡核苷酸进行纯化。
载量超高，从而可达到超高产量和高纯度
选择性经过改良，可通过阴离子交换色谱进行实验室规模的高分辨率寡核苷酸纯化
与高 pH、溶剂和高温相容
具有压力和化学稳定性的整体柱支架采用官能团化乳胶纳米微珠进行包被
DNASwift SAX-1S 寡核苷酸柱
订货信息：
| 分析柱 | |
| DNASwift SAX-1S Monolith Column (5 x 150 mm) | 066766 |
The DNASwift™ SAX-1S is a strong anion-exchange column that provides exceptionally high resolution for the purification of oligonucleotides. The exceptionally high resolution provides superior purity and yields compared to other ion-exchange or reversed-phase columns available. The DNASwift column is ideal for therapeutic and diagnostic research, which have very high purity and yield oligonucleotides purification requirements.
Highest resolution for oligonucleotide purification available, providing high purity and yields.
Exceptionally high capacity provides exceptionally high yields with high purity.
Refined selectivity, as with the DNAPac® column, for high resolution
Compatible with high pH, solvents, and high temperatures.
The DNASwift monolith column is specifically designed to provide exceptionally high resolution, laboratory-scale purification of oligonucleotides by anion-exchange chromatography. The use of oligonucleotides in therapeutic and diagnostic research is rapidly expanding. Oligonucleotides for these areas of research must be of the highest purity. DNASwift monolith columns provide high resolution and capacity, resulting in superior purity and yield compared to other ion-exchange and revered-phase columns available.
The DNASwift column is a unique porous polymer monolith specifically designed for superior performance in oligonucleotide purification. The column is a pressure and chemically stable monolith support coated with functionalized latex nanobeads. These latex nanobeads, beads with strong anion-exchange functional groups, optimized for oligonucleotide separations, are similar to those of the industry leading DNAPac columns. Similarly, the nanobeads contribute to the DNASwift column's exceptionally high resolution and selectivity control. The monolith, a polymer cylinder with interconnected flow through channels, provides fast mass transfer which contributes to the exceptionally high resolution of the DNASwift column. The porous monolith also offers low back pressure, allowing increased flow rates with minimal loss of resolution. The combination of functionalized latex nanobeads and monolith technology results in the DNASwift column having very high capacity, exceptionally high resolution, and refined selectivity control, which results in superior purity and yield of full length oligonucleotide products purified from crude oligonucleotide samples. This makes the DNASwift column ideal for oligonucleotide, therapeutic, and diagnostic research. Additionally, it provides DNASwift columns with the capability to successfully purify difficult oligonucleotide products.
| DNASwift SAX-1S Specifications | |
|---|---|
| Surface chemistry | Quaternary amine |
| Column dimension | 5 × 150 mm |
| Base matrix | Polymethacrylate |
| Oligonucleotide binding capacity | ~20 mg/mL 20-mer |
| Total binding capacity per column | ~50 mg 20-mer |
| Bed height | 130 mm |
| Bed volume | 2.5 mL |
| pH Range | 6–12.4 for operation 2–14 for cleaning NOTE: [Salt]≥Equimolar to [NaOH] required |
| Recommended Ffow rate | 0.5–2.5 mL/min |
| Maximum flow rate | 3 mL/min |
| Operating column pressure | ≤ 1500 psi 10.3 MPa |
| Maximum operating temperature | 85 °C |
| Solvent compatibility | Most common organic solvents (e.g., CH3CN, CH3OH) |
| Product Data Sheets | |
|---|---|
 | DNASwift Monolith Column for Oligonucleotide Purification Data Sheet |
| Guides | |
|---|---|
| DNASwift Monolithic Column for Oligonucleotide Purification Product Manual |
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