Over the last decades, an increasing number of generic drug formulations have been released on the pharmaceutical market. These products are generally analyzed with compendia methods. This Application Note describes the method transfer of a USP HPLC method for amlodipine besylate tablets to a state-of-the-art UHPLC method. Adjustments on column dimension and method parameters were carried out within the permitted limits in order to avoid the need for a lengthy revalidation process. The Agilent 1290 Infinity II LC facilitated smooth transfer from one method to the other. System suitability criteria were investigated and met with both HPLC and UHPLC.
【设备更新】不同酵母菌种对谷物秸秆体外发酵的改良效果评价Evaluation of Different Yeast Species for Improving In vitro Fermentation of Cereal Straws玉米秸秆(玉米,品种科香甜玉米No. 1,长沙,中国)和水稻秸秆(水稻,品种向125S/BAR-1,长沙,中国)使用格哈特全自动纤维仪Fibretherm测定NDF和ADF含量,并在NDF分析中加入亚硫酸钠和α-淀粉酶。将过滤后的残留物在105°C下干燥12小时并称重以进行体外干物质消化率(IVDMD)测定。测定干燥残留物中的NDF含量,以计算体外NDF消化率(IVNDFD)。蛋白质按凯氏定氮法,蛋白质转换系数6.25VFA挥发性脂肪酸以及NH3-N氨态氮可使用格哈特VAPODEST蒸馏仪进行样品蒸馏前处理