(水凝胶弹簧圈栓塞)缠绕密度对脑动脉瘤流体力学特性的影响的定量研究:体外稳定流动研究
Over the past 15 years, coil embolization hasemerged as an effective treatment option for cerebralaneurysms that is far less invasive than the long-standingconvention of surgical clipping. However, aneurysm recurrenceafter coil embolization is not uncommon: recurrencerates as high as 50% have been reported in the literature. Onefactor that may contribute to recurrence after coiling isresidual flow into the aneurysmal sac. At present, there islimited quantitative knowledge of the relationship betweencoil packing density and aneurysmal inflow. We present anin vitro fluid dynamic study of basilar tip aneurysm modelsthat elucidates this relationship. At physiologically normalflow rates, we found that a packing density of 28.4%decreased aneurysmal inflow by 31.6% in a wide-neck model,and that a packing density of 36.5% decreased aneurysmalinflow by 49.6% in a narrow-neck model. Results alsoindicated that coiling reduced aneurysmal inflow moresignificantly at lower parent vessel flow rates, and thatcoiling reduced neck-plane velocity magnitudes more significantlyfor narrow-neck aneurysms. Our study provides novelquantitative information that could ultimately contribute toimproved outcomes for patients with cerebral aneurysms byenabling more effective coil embolization.