BCEIA2023磁共振波谱学分会精彩预告:磁共振技术助力绿色健康生活
第二十届北京分析测试学术报告会暨展览会(BCEIA 2023) 将于2023年9月6-8日在北京 中国国际展览中心(顺义馆)召开。作为中国分析与生化技术交流与展示的“峰会”,BCEIA2023将营造浓郁的学术会展氛围,同期举办大会报告、分会报告、高峰论坛、同期会议、墙报展等精彩学术活动,面向世界科技最前沿,邀请国内外顶尖学者分享最具前瞻性的研究进展。自20世纪40年代以来,磁共振技术的持续发展对多学科的发展起到了巨大的推动作用,核磁共振(NMR)、电子顺磁共振(EPR/ESR)、磁共振成像(MRI)等技术和新应用不断推陈出新,在生命科学、环境、材料等多个学科发挥越来越重要的作用。2023年9月7-8日,BCEIA2023学术报告会——磁共振波谱学分会将在学术会议区E-303会议室举行,会议聚焦“磁共振技术助力绿色健康生活”主题,围绕生物磁共振技术与应用、小分子磁共振技术与应用、EPR技术与应用、磁共振成像、基于核磁共振的代谢组学研究等几个专题方向,邀请到20多位国内波谱领域资深科学家及青年才俊带来精彩报告。特邀报告人报告摘要Prof. Xia, Bin is from Peking University. He graduated from the Department of Biology of Peking University in 1989 with a bachelor's degree in physiology and biophysics. In 1997, he received PhD in biophysics from University of Wisconsin-Madison in the United States. From 1997 to 2001, he did postdoctoral research at The Scripps Research Institute, USA.In 2001, he was awarded professorship of The Cheung Kong Scholars Program, and became a joint professor at College of Chemistry and Molecular Engineering and School of Life Sciences of Peking University. In the same year, he was awarded the Outstanding Youth Fund from National Natural Science Foundation of China. In December 2002, he was appointed director and chief scientist of Beijing Nuclear Magnetic Resonance Center, a national large scientific instrument center established at Peking University, jointly funded by Ministry of Science and Technology, Ministry of Education, Chinese Academy of Sciences and Department of Health of The General Logistics Department of PLA .At present, he is also a member of the professional committee of magnetic spectroscopy of Chinese Physics Society, a member of the professional committee of molecular biophysics of the Chinese Biophysics Society, a member of the professional committee of nuclear magnetic resonance instruments of the Chinese Instrumentation Society, and member of the editorial boards of Journal of Biological Chemistry and Chinese Journal of Magnetic Resonance.Professor Xia's main research direction is to study the three-dimensional structures and interactions of proteins, using nuclear magnetic resonance (NMR) technology, combined with other structural biology, biochemistry and molecular cell biology research methods, in order to understand their structure andfunction relationship and reveal the molecular mechanisms of their biological functions. In the past decade, he has mainly focused on studying the structure and function relationships of transcriptional regulatory factors, and the molecular mechanisms of bacterial xenogeneic silencing and counter-silencing.专家简介夏斌,北京大学教授、博士生导师。1989年毕业于北京大学生物系,获生理学与生物物理学专业学士学位。1997年,获美国University of Wisconsin-Madison生物物理专业博士学位。1997年至2001年,在美国The Scripps Research Institute做博士后研究。2001年,被聘为教育部“长江学者奖励计划”特聘教授,同时被聘为北京大学化学与分子工程学院博士生导师和北京大学生命科学学院博士生导师。同年,荣获国家自然科学基金委员会“杰出青年基金”。2002年12月,被任命为由国家科技部、国家教育部、中国科学院和总后卫生部共同出资,依托于北京大学建立的国家大型科学仪器中心“北京核磁共振中心”主任兼首席科学家。目前还担任中国物理学会波谱学专业委员会委员、中国生物物理学会分子生物物理专业委员会委员、中国仪器仪表学会核磁共振仪器专业委员会委员、《Journal of Biological Chemistry》及《波谱学杂志》杂志编委。夏斌教授主要研究方向是利用核磁共振(NMR)技术,结合其它结构生物学、生物化学及分子细胞生物学研究手段,研究蛋白质三维空间结构及相互作用,以期理解其结构与功能关系,揭示其生物学功能的分子机理。近十年来,主要研究转录调控因子选择性识别DNA的结构与功能关系,以及细菌外源基因沉默与抗沉默的分子机制。报告摘要Human metabonome contains thousands of metabolites with numerous functions, huge concentration range, diverse properties and matrices. Quantitative metabolomic analysis is essential for understanding the molecular aspects of mammalian biology, physiology, pathophysiology of various diseases. During last decades, metabolomics science has made huge progress in both technical and application areas. To achieve accurate quantitative metabolomic analysis, however, developing efficient novel analytical technologies remains to be one of the most urgent and extremely challenging tasks. NMR and MS are the dominant analytical tools. This presentation will deal with the requirements of quantitative metabonomics and strategies to fulfill such tasks followed with some recent methodological advances in NMR. We will also discuss the major challenges metabolomic analysis is facing and possible strategies to overcome such problems with some integrated multiple-omics results presented. We will report some important applications here专家简介唐惠儒,复旦大学特聘教授、国家杰青、“精准医学”及“前沿生物技术”国家重点研发计划项目首席科学家、英国皇家化学会会士。研究代谢物结构及代谢组学30余年,发表Nature、Nat Microbiol、PNAS等SCI论文210余篇,被引1.3万余次(h指数~64)。获批国内外发明专利多项。曾任英国BBSRC食品研究所及帝国理工学院医学部Senior Scientist、“中科院生物磁共振分析重点实验室”创建主任、科技部973等项目评审专家。现任中国生物物理学会代谢组学分会会长、中国生物化学与分子生物学会脂质与脂蛋白委员会常委、中国抗癌协会肿瘤代谢分会及中国营养学会基础营养分会常务理事、国际实验磁共振大会(ENC)执委,Metabolomics、Arch Pharm及《基础医学与临床》等编委,Nutrition Metabol及Phenomics等副主编。报告摘要19F NMR is a powerful technique to study the structure, dynamics and interactions of complex biological systems that are not accessible by conventional 13C, 15N or 1H spectroscopy. In the last ten years, 19F NMR has advanced significantly, both in terms of 19F labeling methods and applications. In this talk, I will demonstrate some examples of how 19F labeling can be used to probe biomacromolecular structure, interaction, dynamics, especially in living cells, which is a challenging task for other biophysical methods if not impossible.专家简介李从刚,中国科学院武汉精密测量科学与技术创新研究院(原武汉物理与数学研究所)研究员、国家杰青。1997年获武汉大学化学系学士学位;2007年获美国佛罗里达州立大学化学与生物化学系博士。2007-2011年在美国北卡罗莱纳大学(Chapel Hill)化学系从事博士后研究。目前主要从事生物大分子的核磁共振方法与应用研究,主要包括细胞内蛋白质的结构,动力学及相互作用的核磁共振方法研究及重要功能的生物大分子分子作用机理研究。报告摘要 泛素(Ub)在细胞信号传导的许多方面是不可或缺的。先前的研究得出结论,Ub折叠涉及三种状态,但未能提供折叠中间体的结构细节。在我的汇报中,我将展示点突变、磷酸化修饰以及C末端延伸对Ub毫秒动力学的各种影响,即Ub天然状态和新出现的另一种结构状态之间的相互转换。值得注意的是,凡是能促进Ub毫秒动态结构变化的突变也能够降低蛋白质的熔点,而能够抑制Ub动态变化的突变则能够提升蛋白的熔点。因此,天然状态与另一种结构状态之间互选转换的中间构象状态应该就是大家长期寻求的Ub折叠中间体,是否经过中间态决定了蛋白的稳定性。此外,我还将展示我们实验室最新筛选发现的去磷酸化泛素的酶。专家简介 唐淳,北京大学化学与分子工程学院博雅特聘教授,北京大学定量生物学中心和生命联合中心研究员,基金委杰出青年,科技部首席科学家、万人计划科技创新领军人才,以及美国霍华德休斯医学院国际青年科学家。2010-2020年任中国科学院武汉物理与数学研究所研究员,中科院生物磁共振分析重点实验室主任。唐淳实验室重点关注蛋白质及生物大分子的结构如何动态变化的,以及相对应的非平衡态能量景观,阐释蛋白质行使功能的内在原子分子机制,是国际上最早将顺磁核磁共振用于蛋白质构象可视化的实验室之一 观察和表征了存在比例不到1% 的蛋白质构象状态,捕获了蛋白之间的极弱相互作用,解析了结合常数仅为25 mM的蛋白复合体结构。实验室还发展了与单分子荧光、质谱交联等物理化学技术联用的整合方法,表征不同时间、空间尺度的生物大分子结构的级联动态变化。已发表论文80余篇,刊登在Nature、PNAS、JACS、Angew Chem等期刊,累计引用6000余次。报告摘要本报告将基于靶向BK通道beta4亚基胞外区与毒素肽MarTX及CTX突变体的NMR溶液结构,开展抗癫痫肽研制研究。报告将从结构-多肽活性-药物递送等阐述抗癫痫肽的设计与推广。专家简介2001.6博士毕业于中科院上海有机所,2001.8-2005.10,每个约翰霍普金斯大学医学院博士后,2005.10-2006.8 美国加州Salk Inst for Biological Studies 研究助理,2006.8中科院上海有机所研究员报告摘要Water is ubiquitous yet essential for the existence of known life forms. It is crucial both structurally and functionally for biomolecules, including proteins, nucleic acids, and membranes. Thus, understanding water dynamics and structure is an important topic in the biomolecular systems, as many essential biological processes take place with the aid of water. However, observing “bound” water molecules in such biosystems as well as site-specific chemical exchange between water molecules and specific proton sites in the biosystems is rather challenging, especially in the presence of strong 1H-1H dipolar interactions associated with the relatively rigid biosystems and because of the very high concentration of highly mobile “bulk” water molecules surrounding the biosystems. Here we report our recent development in solid-state MAS NMR techniques that allow us to directly detect the bound water molecules that are relatively stable over the NMR timescale (on the order of milliseconds) in an extensively hydrated lipid bilayer environment [1] and to characterize the site-specific chemical exchange between water molecules and specific proton sites in biosystems [2], an important parameter in the dynamic relationship between biomolecules and their surrounding environment. These new techniques provide an important tool for charactering the role of water in the structureand function of the biosystems.专家简介Riqiang Fu received his B.S. degree in Electrical Engineering from University of Science and Technology (USTC) of China in 1986 and his PhD degree in 1992 with Prof. Chaohui Ye at Wuhan Institute of Physics. Currently he is a Research Faculty III at National High Magnetic Field Lab, Tallahassee, Florida. He specializes in solid-state NMR methodology development and NMR applications in materials science (such as lithium ion battery materials) and biological systems (such as membrane proteins). He has authored/co-authored 200 peer reviewed papers, five of which were featured as Cover story in Journal of Magnetic Resonance (2005, 2012, and 2021) and in Journal of American Chemical Society(2014 and 2019).报告摘要RNA的结构和构象动态是其发挥正常生理功能和参与异常病理过程的关键基础。亨廷顿舞蹈症、渐冻症和脊髓小脑共济失调等是一类由短串联重复序列扩增引起的神经退行性疾病,其中RNA重复序列通过形成特殊的二级或三级结构参与病理过程,如RNA相分离和蛋白募集。因重复序列具有高度的结构多样性和构象动态性,液体核磁共振技术是研究这类特殊RNA的有力工具。本工作中,我们将报道亨廷顿舞蹈症和渐冻症中RNA重复序列的结构特点及其参与致病分子途径的结构基础。专家简介郭沛,中国科学院杭州医学研究所副研究员。2012年于华中师范大学化学系获学士学位,2016年于香港中文大学化学系获博士学位,2017至2019年在香港中文大学化学系从事博士后研究。聚焦于利用液体核磁共振技术和计算方法研究疾病相关核酸分子的结构和构象动态,以及基于结构信息指导的核酸分子生物功能和靶向治疗策略,在JACS、PNAS、STTT和NAR等期刊发表论文30余篇。报告摘要报告摘要WRKY转录因子在与生物和非生物胁迫反应相关的各种植物信号通路中起着至关重要的作用。许多WRKY成员的转录活性由一类固有无序VQ蛋白调节。虽然已知VQ蛋白与WRKY蛋白DNA结合结构域(DBD)相互作用,也称为WRKY结构域,但缺乏有关VQ-WWRKY相互作用的结构信息,调节机制仍然未知。我们利用核磁共振方法研究了拟南芥WRKY33与其调节性VQ蛋白伴侣SIB1之间相互作用。我们发现了与WRKY33 DBD形成稳定复合物所需的SIB1最小序列,该序列不仅包括共识“FxxhVQxhTG”VQ基序,还包括其前一个区域。我们证明了WRKY33 DBD的βN链和延伸的βN-β1环形成了SIB1对接位点,并基于核磁共振顺磁弛豫增强突变数据建立了复合体的结构模型。基于该模型,我们进一步确定了SIB1的N末端区域中带正电荷的残基簇对于SIB1-WRKY33-DNA三元复合物的形成至关重要。这些结果为SIB1增强的WRKY33转录活性的机制提供了框架。专家简介胡蕴菲,2010年获北京大学生物化学与分子生物学博士学位,自2019年6月起在中国科学院精密测量科学与技术创新研究院任研究员,博士生导师,从事蛋白质动态/瞬态结构、相互作用和功能关系的液体NMR研究。欢迎扫码报名参加BCEIA2023