用钠灯和卤素灯测定吡柔比星的旋光
An emission line of light source such as a sodium lamp or a mercury lamp is usually used to measurethe optical rotation of pharmaceutical products. However, the Japanese Pharmacopeia and the EuropeanPharmacopeia only mention the use of a sodium lamp as the light source. A polarimeter using a halogen lamp and a band pass filter (BPF) can also be used, as mentioned in theUnited States Pharmacopeia. However, the measurement error from the transmission property, that is thedifference between the center wavelength of the BPF and the wavelength of emission line, cannot beavoided.Herein, the optical rotation of pirarubicin was measured using a sodium lamp and a halogen lamp, andthe measurement error between the results was evaluated.