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3D药筛新技术——类器官芯片(Chiwan Chiang报告)

主讲人:Chiwan Chiang, MSc. 上传时间:2019/12/24 10:03
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课程详情

从2D到3D,高内涵药物筛选技术简谈摘要:随着仪器制造技术,生物检测手段和计算机数据分析软件的不断革新。旨在以检测和分析多靶点多指标,更好的对化合物活性进行综合评价的高内涵药物筛选技术应运而生。在保持细胞结构和功能完整性的前提下,同时检测被筛选物对细胞形态、生长、分化、迁移、凋亡、代谢途径及信号转导等各项指标。而由此,2D细胞培养技术被大量应用在药物筛选、开发和疾病治疗的研究中。但是这种模型无法准确描述和模拟细胞在体内复杂的微环境和各种复杂生物学过程。因此,细胞球、类器官芯片等3D细胞培养技术不断更新,以研究细胞迁移、黏附和对药物反应的准确描述。

讲师简介:

Chiwan is a Scientist in the Model Development team at Mimetas where she develops 3D CNS on-a-chip models. She received her master’s degree in Biomedical Sciences at the University of Groningen (The Netherlands). Her main interest during the bachelor’s degree was Immunology, where she gained research experience at the Weatherall Institute of Molecular Medicine, University of Oxford. During her master’s she focused on research in Neuroscience, the aim of her dissertation was to assess the role of astrocytes in axonal damage in Vanishing White Matter disease at the VU University Medical Center Amsterdam. Besides, she investigated the role of microglia in Glioblastoma by isolating cells from patient’s tumor material at the University Medical Centre of Groningen. At Mimetas she developed an 3D CNS model for high-throughput neurotoxicity and seizure liability testing. In addition, she focusses on developing 3D Parkinson’s disease model for screening of novel drug candidates.

相关领域:

(环保/水工业)-(废水)

相关仪器:

(化学分析仪器)-(光谱仪器)-(便携式分光光度计)

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