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核苷酸焦磷酸酶2抗体
英文名称 ENPP2
中文名称 核苷酸焦磷酸酶2抗体
别 名 ATX; ATX X; Autotaxin; Autotaxin t; E NPP 2; E-NPP 2; Ectonucleotide pyrophosphatase/phosphodiesterase 2; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Enpp2; ENPP2_HUMAN; Extracellular lysophospholipase D; LysoPLD; NPP2; PD IALPHA; PDNP2; Phosphodiesterase I alpha; Phosphodiesterase I/nucleotide pyrophosphatase 2; Plasma lysophospholipase D.
研究领域 肿瘤 心血管 细胞生物 神经生物学 生长因子和激素
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 95kDa
细胞定位 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ENPP2:131-230/863
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
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