β淀粉样蛋白前体结合蛋白B-1抗体
英文名称 APBB1 interacting protein 1
中文名称 β淀粉样蛋白前体结合蛋白B-1抗体
别 名 AB1IP; Amyloid beta A4 precursor protein binding family B member 1 interacting protein; Amyloid beta precursor protein binding family B member 1; APBB1 interacting protein 1; OTTHUMP00000019344; PREL 1; PREL1; Proline rich EVH1 ligand 1; Proline rich protein 73; Rap1 GTP interacting adapter molecule; RAP1 interacting adaptor molecule; RARP 1; RARP1; Retinoic acid responsive proline rich protein 1; AB1IP_HUMAN.
研究领域 肿瘤 细胞生物 信号转导 结合蛋白 G蛋白偶联受体
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Sheep,
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RIAM/APBB1 interacting protein 1:301-400/666
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 APBB1IP is a 666 amino acid protein that contains one PH domain, one Ras-associating domain and belongs to the MRL family. Encoded by a gene that maps to human chromosome 10p12.1, APBB1IP likely functions in signal transduction from Ras activation to Actin cytoskeletal remodeling. APBB1IP also suppresses insulin-induced promoter activities, by way of SRE and AP1. The two proline-rich regions of APBB1IP are necessary for AP1 transcription suppression. Ubiquitously expressed, with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes, APBB1IP is induced by all-trans-retinoic acid (ATRA) and mediates Rap 1-induced adhesion. APBB1IP also interacts with RAP 1A, Profilin-1, VASP and Mena.
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上海联迈生物工程有限公司
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2017-09-26
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