磷酸化过氧化酶活化增生受体γ抗体
英文名称 Phospho-PPAR Gamma (Ser112)
中文名称 磷酸化过氧化酶活化增生受体γ抗体
别 名 PPAR Gamma (Phospho Ser112); PPAR Gamma (Phospho S112); PPAR Gamma (Phospho-Ser112); CIMT1; HUMPPARG; NR1C3; Nuclear receptor subfamily 1 group C member 3; PAX8/PPARG Fusion Gene; Peroxisome Proliferator Activated Receptor gamma; PPAR gamma; PPARG; PPARG1; PPARG2; PPARG3l; PPARG_HUMAN.
产品类型 磷酸化抗体
研究领域 肿瘤 免疫学 细胞凋亡 激酶和磷酸酶
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Rabbit, Guinea Pig,
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg /Test IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human PPAR Gamma around the phosphorylation site of ser112:PA(p-S)PP
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008].
类固醇受体(Steroid Receptors)
过氧化物酶体增殖物激活受体γ(PPARγ)主要存在于白色脂肪组织,PPARγ对于脂肪生成、血糖稳定、炎症反应、动脉粥样硬化和肿瘤等的发生都起到重要的作用。主要在脂肪细胞内表达。PPARγ是噻唑烷二酮类药物(TZDs)作用的药靶,又是脂肪细胞分化的重要调节因子。经研究发现,PPARγ在肥胖及胰岛素抵抗的发病机制中具有十分重要的意义,是治疗糖尿病、肥胖等代谢性疾病的重要药靶。
过氧化物酶体增殖物激活受体γ(PPARγ)属Ⅱ型核受体超家族成员,主要在脂肪细胞内表达。PPARγ是噻唑烷二酮类药物(TZDs)作用的药靶,又是脂肪细胞分化的重要调节因子。现有研究(包括一次于美国加州大学进行的研究)发现PPARγ在肥胖及胰岛素抵抗的发病机制中具有十分重要的意义,是治疗糖尿病、肥胖等代谢性疾病的重要药靶。目前,该受体蛋白质水平的筛选模式已经建立,并正在建立该受体的报告基因的细胞水平筛选评价模式。