踝蛋白抗体
英文名称 Talin
中文名称 踝蛋白抗体
别 名 TLN 1; ILWEQ; Talin 1; TLN; TLN1; TLN1_HUMAN.
研究领域 细胞生物 免疫学 转录调节因子 细胞粘附分子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 280kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Talin:1601-1750/2541
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-270 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations.
TALIN-踝蛋白。是重要的细胞骨架肌动蛋白结合蛋白,由两个270kDa的亚单位组成的反向 平行的同源二聚体,与整合蛋白B尾部的结合诱导了整合蛋白胞外结构域构象的改变,起到了对整合蛋白的激活。
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企业名称
上海联迈生物工程有限公司
企业信息已认证
企业类型
信用代码
310117003747946
成立日期
2017-09-26
注册资本
100
经营范围
从事生物科技、医疗科技领域内的技术开发、技术咨询、技术服务、技术转让,仪器仪表、机电设备、机械设备、玻璃制品、电子产品、一类医疗器械、化工产品及原料(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品)的销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海联迈生物工程有限公司
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