核仁磷酸蛋白抗体

核仁磷酸蛋白抗体

英文名称    Nucleophosmin    

中文名称    核仁磷酸蛋白抗体    

别    名    B23; B23; MGC104254; NMP1; NMP1; NO38; NPM 1; NPM; NPM_HUMAN; NPM1; Nucleolar Phosphoprotein B23; Nucleolar Phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin (nucleolar phosphoprotein B23 numatrin); Nucleophosmin; Nucleophosmin/B23.2; Nucleophosmin/nucleoplasmin family member 1; Nucleoplasmin Family Member 1; Nucleoplasmin Family Member 1; Numatrin; Numatrin; OTTHUMP00000161024; OTTHUMP00000161025; OTTHUMP00000223397; OTTHUMP00000223398; TRK fused gene.      

研究领域    肿瘤  细胞生物  免疫学  信号转导  细胞凋亡  细胞周期蛋白  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    32kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/ml    

免 疫 原    KLH conjugated synthetic peptide derived from human NPM:51-150/294     

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

PubMed    PubMed    

产品介绍    This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009].    

核仁磷酸蛋白（nucleophosmin）是雌激素调控的一种核仁蛋白， Nucleophosmin(又称为NPM、B23、Numatrin、NO38)位于核仁的颗粒区,与其他一些核蛋白如C23、P120等可相互作用。NPM是一种主要位于核的核与胞浆穿梭蛋白，能调节ARF-p53肿瘤抑制通路。NPM是一种主要的核仁蛋白，在肿瘤或增殖细胞中的表达量比正常静止细胞中多20多倍。研究资料表明，转录因子YY1在NPM基因的表达中可能发挥作用。 
    NPM可以在细胞核与细胞浆之间穿梭,其定位受细胞周期及一些细胞毒药物的影响。NPM基因在多种人类肿瘤中过表达,因此被公认为肿瘤标志物和癌基因.后来研究发现NPM也具有抑制肿瘤的功能,它的缺失、突变甚至重排与多种肿瘤的发生密切相关.