诱导协同刺激分子配体CD275抗体

诱导协同刺激分子配体CD275抗体

英文名称    ICOS ligand    

中文名称    诱导协同刺激分子配体CD275抗体    

别    名    B7 H2; B7 homolog 2; B7 homologue 2; B7 like protein Gl50; B7 related protein 1; B7-like protein Gl50; B7-related protein 1; B7-H2; B7H2; B7RP 1; B7RP-1; B7RP1; CD 275; CD275; CD275 antigen; GL 50; GL50; ICOS L; ICOS LG; ICOS ligand; ICOSL; ICOSL_HUMAN; Icoslg; Inducible T cell co stimulator ligand; KIAA0653; LICOS; Transmembrane protein B7 H2 ICOS ligand; ICOSLG; ICOS ligand-like; ICOS ligand.      

研究领域    免疫学  转录调节因子  细胞表面分子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Rat,     

产品应用    WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=1μg/Test  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    34kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/ml    

免 疫 原    KLH conjugated synthetic peptide derived from human ICOS ligand:19-120/302     

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

PubMed    PubMed    

产品介绍    ICOS ligand is a member of the B7 family and the immunoglobulin superfamily. Human ICOS ligand is expressed by activated monocytes/macrophages and dendritic cells. It binds to a CD28 like receptor, inducible costimulator molecule (ICOS, AILIM, CRP-1), which is expressed by activated T cells. This interaction plays an important role in the T cell costimulation pathway.
B7协同刺激分子及其相应受体结合所产生的信号在调节T细胞活化及效应性细胞因子分泌中起重要作用，具有负性调节作用的协同刺激分子对免疫应答的适度进行、防止自身免疫疾病的发生具有重要作用。
B7H2可协同刺激CD14 + 细胞增殖，并分泌IL-4、IL-5、IFN-β、TNF-α、GM-CSF和IL-10等细胞因子，但不能协同刺激T细胞上调IL-2的分泌。