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Acclaim Trinity P1 Series
Acclaim Trinity P1 is a unique, high-efficiency, silica-based column designed for pharmaceutical applications such as simultaneous separation of pharmaceutical drug substances and their counterions. This new column, based on nanopolymer silica hybrid (NSH) technology, provides multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchange. As a result, its selectivity can be easily optimized by adjusting mobile phase buffer concentration, pH, and solvent content concurrently or independently. The NSH technology ensures distinctive spatial separation of the anion-exchange and cation-exchange regions, which results in maximum flexibility in method development. The easy-to-optimize selectivity can be used to accelerate chromatographic separations and increase productivity.
NSH Chromatographic Features
Multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchange
Adjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solvent
Ideal selectivity for simultaneous separation of basic, neutral, and acidic analytes
Separation of hydrophilic ionic and ionizable analytes without ion-pairing reagents
Acclaim Trinity P1 Applications
Active pharmaceutical ingredients (API) and counterions (cations or anions)
Screening of pharmaceutical counterions. Both UV and evaporative light scattering (ELS) detectors, in series, are required for simultaneous determination of both drug substances and counterions.
Mixture of acidic and basic drug substances and respective counterions
Drug substances of acidic, basic, and neutral mixtures
High throughput analysis following optimization of the selectivity and resolution. The flow rate can then be increased, and the analysis time shortened.
| Acclaim Trinity P1 Column – Superior Performance for Pharmaceutical Applications Specifications | |
|---|---|
| Column chemistry | SCX, WAX and RP Mixed-Mode |
| Operating pressure limit (recommended) | 4500 psi (4000 psi) |
| Operating pH range (recommended) | 2.5 – 7.0 (3.0 to 6.2) |
| Operating flow rate range (recommended) | 0.3 – 1.5(0.4 – 0.8) mL/min for 3.0-mm i.d. formats 0.15 – 0.80 (0.2 to 0.4) mL/min for 2.1-mm i.d. formats |
| Analytical Columns | |
|---|---|
| Acclaim Trinity P1, 3μm, 3.0 x 150mm | 075563 |
| Acclaim Trinity P1, 3μm Analytical, (3.0 x 100mm) | 071387 |
| Acclaim Trinity P1, 3μm Analytical, (3.0 x 50mm) | 071388 |
| Acclaim Trinity P1, 3μm, 2.1 x 150mm | 075564 |
| Acclaim Trinity P1, 3μm Analytical, (2.1 x 100mm) | 071389 |
| Acclaim Trinity P1, 3μm, 2.1 x 50mm | 075565 |
| Guard Columns | |
|---|---|
| Acclaim Trinity P1, 3μm Guard Cartridges, (3.0 x 10mm), 2ea (Use Holder V-2) | 071390 |
| Acclaim Trinity P1, 3μm Guard Cartridges, (2.1 x 10mm), 2ea (Use Holder V-2) | 071391 |
| Acclaim SST Guard Cartridge Holder V-2 | 069580 |
| Acclaim Guard Kit (Holder and coupler) V-2 | 069707 |
| Guard to Analytical Column Coupler V-2 | 074188 |
企业名称
上海希言科学仪器有限公司
企业信息已认证
企业类型
有限责任公司(自然人投资或控股)
信用代码
91310117301434080L
成立日期
2014-05-26
注册资本
人民币100.0000万元整
经营范围
一般项目:技术服务、技术开发、技术咨询、技术交流、技术转让、技术推广;仪器仪表销售;实验分析仪器销售;光学仪器销售;货物进出口;技术进出口。(除依法须经批准的项目外，凭营业执照依法自主开展经营活动)
上海希言科学仪器有限公司
公司地址
上海市松江区九亭镇涞寅路1025号立同国际商务大厦3067室
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