神经管畸形相关蛋白VANGL2抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 神经管畸形相关蛋白VANGL2抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The Vang family of proteins are integral membrane proteins that are homologs of the Drosophila tissue polarity gene strabismus. The gene encoding for Van Gogh-like protein 1 (Vangl1), also designated Strabismus 2 (STB2), localizes to chromosome 1p11-p13.1. Van Gogh-like protein 2 (Vangl2), also designated Strabismus1 (STB1), localizes on chromosome 1q22-q23. Vangl1 is expressed in testis and ovary, but also in gastric and pancreatic cancer. Vangl proteins play a key developmental role in establishing planar cell polarity 神经管畸形相关蛋白VANGL2抗体(PCP) and in regulating convergent extension (CE) movements during embryogenesis. Vangl1 and Vangl2 are both down-regulated in several cancer cell lines and primary tumors.
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity,神经管畸形相关蛋白VANGL2抗体 particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process.

Also known as:

Homolog of Drosophila strabismus; KIAA1215; Loop tail associated protein; loop tail protein 1 homolog; Loop-tail protein 1 homolog; LPP 1; LPP1; LTAP; STB 1; STB1; STBM 1; STBM; STBM1; Strabismus 1;神经管畸形相关蛋白VANGL2抗体 van Gogh like protein 2; Van Gogh-like protein 2; Vang (van gogh, Drosophila) like 2; Vang like 2 (van gogh, Drosophila); vang like 2; vang like protein 2; Vang-like protein 2; VANG2_HUMAN; VANGL 2; Vangl2.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Cow, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human VANGL2.

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神经管畸形相关蛋白VANGL2抗体Predicted Molecular Weight: 60kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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