磷酸化细胞周期检控Rad17蛋白抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化细胞周期检控Rad17蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex 磷酸化细胞周期检控Rad17蛋白抗体onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013].

磷酸化细胞周期检控Rad17蛋白抗体Also known as:

CCYC; Cell cycle checkpoint protein; Cell cycle checkpoint protein RAD17; HRAD 17; HRAD17; R24L; Rad 17; Rad 24; RAD1 (S. pombe) homolog; RAD17 homolog; Rad17 like protein; RAD17Sp; Rad24; RF C activator 1 homolog; RF C/activator 1 homolog.

Specificity:

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Rabbit Polyclonal IgG, 磷酸化细胞周期检控Rad17蛋白抗体affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human Rad17 around the phosphorylation site of Ser645.

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磷酸化细胞周期检控Rad17蛋白抗体Predicted Molecular Weight: 77kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user

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