磷酸化原癌基因c-Met相关酪氨酸激酶抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化原癌基因c-Met相关酪氨酸激酶抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD磷酸化原癌基因c-Met相关酪氨酸激酶抗体 (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. Ron expression has been documented磷酸化原癌基因c-Met相关酪氨酸激酶抗体 in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uterus.

Also known as:

p-MST1R(Tyr1353); RON (phospho Y1353); MST1R(phospho S1349); c met related tyrosine kinase; CD136 antigen; CDw136; Macrophage stimulating 1 receptor; Macrophage stimulating protein receptor alpha chain; MACROPHAGE STIMULATING PROTEIN RECEPTOR; Macrophage stimulating磷酸化原癌基因c-Met相关酪氨酸激酶抗体 protein receptor beta chain; MSP receptor; MST1R; p185 RON; PTK 8; ptk8; PTK8 protein tyrosine kinase 8; RON; RON protein tyrosine kinase; Stem cell derived tyrosine kinase.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Horse, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human MST1R around the phosphorylation site of Tyr1353 .

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磷酸化原癌基因c-Met相关酪氨酸激酶抗体Predicted Molecular Weight: 150kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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