Quantity size:
0.1ml
Concentration:
1mg/ml 磷酸化胰岛素受体β(Tyr1361)抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity磷酸化胰岛素受体β(Tyr1361)抗体. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.
Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth 磷酸化胰岛素受体β(Tyr1361)抗体factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
磷酸化胰岛素受体β(Tyr1361)抗体Also known as:
Insulin Receptor (phospho Y1361); Insulin Receptor (phospho Try1361); CD 220; CD220; CD220 antigen; HHF 5; HHF5; HIR B; INSR; INSR; Insulin receptor; Insulin receptor subunit beta; IR; INSR_HUMAN.
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, .
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Immunogen: KLH conjugated synthetic peptide derived from human Phospho-.
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Predicted Molecular Weight: 68kDa.
磷酸化胰岛素受体β(Tyr1361)抗体Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
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kl145Ra01Ⅸ型胶原α1(COL9α1)多克隆抗体Polyclonal Antibody to Collagen Type IX Alpha 1 (COL9a1)
kl146Hu01Ⅷ型胶原α1(COL8α1)多克隆抗体Polyclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1)
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kl148Hu01Ⅵ型胶原α3(COL6α3)多克隆抗体Polyclonal Antibody to Collagen Type VI Alpha 3 (COL6a3)
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kl152Mu01Ⅴ型胶原α2(COL5α2)多克隆抗体Polyclonal Antibody to Collagen Type V Alpha 2 (COL5a2)
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kl156Hu01Ⅹ型胶原(COL10)多克隆抗体Polyclonal Antibody to Collagen Type X (COL10)
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更多
企业名称
上海康朗生物科技有限公司
企业信息已认证
企业类型
信用代码
310112001510759
成立日期
2015-05-29
注册资本
100
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