亨廷顿(舞蹈症)相互作用蛋白1抗体

Quantity size:

0.2ml

Concentration:

1mg/ml  亨廷顿(舞蹈症)相互作用蛋白1抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product huntingtin. HIP1 (huntingtin-interacting protein 1), a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels, and exhibits nearly identical subcellular fractionation as huntingtin. The huntingtin-HIP1 亨廷顿(舞蹈症)相互作用蛋白1抗体interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking; the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo亨廷顿(舞蹈症)相互作用蛋白1抗体. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.

亨廷顿(舞蹈症)相互作用蛋白1抗体Also known as:

Huntingtin Interacting Protein HIP1; HIP I; HIP-1; HIP-I; hip1; HIP1/PDGFRB fusion gene; HIP1/PDGFRB fusion gene, included; HIP1_HUMAN; HIPI; Huntingtin interacting protein 1; Huntingtin-interacting protein 1; Huntingtin-interacting protein I; ILWEQ; KIAA4113; MGC126506; MGC27616; mKIAA4113.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, .

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Immunogen: KLH conjugated synthetic peptide derived from human HIP1 (40.

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亨廷顿(舞蹈症)相互作用蛋白1抗体Predicted Molecular Weight: 116kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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