通用转录因子3C多肽5/TFIIIC90抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 通用转录因子3C多肽5/TFIIIC90抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence通用转录因子3C多肽5/TFIIIC90抗体  of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP),通用转录因子3C多肽5/TFIIIC90抗体  TFIIB-related factor 1 (BRF1) and TFIIIB’’, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.

Also known as:

FLJ20857; General transcription factor 3C polypeptide 5; General transcription factor IIIC polypeptide 5 63kDa; GTF3C5; TF3C epsilon; TF3C-epsilon; TF3C5_HUMAN; TFIIIC 63 kDa subunit; TFiiiC2 63通用转录因子3C多肽5/TFIIIC90抗体 ; TFIIIC63; TFIIICepsilon; Transcription factor IIIC 63 kDa subunit; Transcription factor IIIC epsilon subunit; Transcription factor IIIC subunit epsilon.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, .

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Immunogen: KLH conjugated synthetic peptide derived from human GTF3C5.

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通用转录因子3C多肽5/TFIIIC90抗体 Predicted Molecular Weight: 59kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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