通用转录因子3C多肽4/TFIIIC90抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 通用转录因子3C多肽4/TFIIIC90抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of 通用转录因子3C多肽4/TFIIIC90抗体five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB’’, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.

通用转录因子3C多肽4/TFIIIC90抗体Also known as:

EC 2.3.1.48; FLJ21002; General transcription factor 3C 4; General transcription factor 3C polypeptide 4; General transcription factor IIIC, polypeptide 4, 90kDa; GTF3C4; KAT12; MGC138450; OTTHUMP00000022434; TF3C delta; TF3C-delta; TF3C4_HUMAN; TFIII90; TFIIIC 90 kDa subunit; TFiiiC2 90; TFIIIC290; TFIIIC90; TFIIICdelta; Transcription factor IIIC 90 kDa subunit; Transcription factor IIIC subunit delta.

Specificity:

●

Rabbit Polyclonal IgG,通用转录因子3C多肽4/TFIIIC90抗体 affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, Dog, Horse, Rabbit, .

●

Immunogen: KLH conjugated synthetic peptide derived from human GTF3C4.

●

Predicted Molecular Weight: 92kDa.

通用转录因子3C多肽4/TFIIIC90抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl549Mu01无翅型MMTV整合位点家族成员5A(WNT5A)多克隆抗体Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A)

kl549Ra01无翅型MMTV整合位点家族成员5A(WNT5A)多克隆抗体Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 5A (WNT5A)

kl552Hu01无翅型MMTV整合位点家族成员11(WNT11)多克隆抗体Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 11 (WNT11)

kl553Hu01无翅型MMTV整合位点家族成员10B(WNT10B)多克隆抗体Polyclonal Antibody to Wingless Type MMTV Integration Site Family, Member 10B (WNT10B)

kl574Hu01线粒体外膜转位酶70A(TOMM70A)多克隆抗体Polyclonal Antibody to Translocase Of Outer Mitochondrial Membrane 70A (TOMM70A)

kl643Hu01核糖体蛋白L23A(RPL23A)多克隆抗体Polyclonal Antibody to Ribosomal Protein L23A (RPL23A)

kl657Hu01瘤变抑制因子14(ST14)多克隆抗体Polyclonal Antibody to Suppression Of Tumorigenicity 14 (ST14)

kl710Hu01C-型凝集素域家族11成员A(CLEC11A)多克隆抗体Polyclonal Antibody to C-Type Lectin Domain Family 11, Member A (CLEC11A)

kl745Hu01G蛋白偶联受体家族C5组成员A(GPRC5A)多克隆抗体Polyclonal Antibody to G Protein Coupled Receptor, Family C, Group 5, Member A (GPRC5A)

kl750Hu01RAD51同源物(RAD51)多克隆抗体Polyclonal Antibody to RAD51 Homolog (RAD51)

kl751Hu01RAD23同源物B(RAD23B)多克隆抗体Polyclonal Antibody to RAD23 Homolog B (RAD23B)

kl797Hu01Pim-2原癌基因(PIM2)多克隆抗体Polyclonal Antibody to Pim-2 Oncogene (PIM2)

kl859Hu01基质重塑关联蛋白5(MXRA5)多克隆抗体Polyclonal Antibody to Matrix Remodelling Associated Protein 5 (MXRA5)

kl861Hu01粘蛋白13(MUC13)多克隆抗体Polyclonal Antibody to Mucin 13, Cell Surface Associated (MUC13)

kl886Hu01层粘连蛋白受体1(LAMR1)多克隆抗体Polyclonal Antibody to Laminin Receptor 1 (LAMR1)

kl892Hu01角蛋白81(KRT81)多克隆抗体Polyclonal Antibody to Keratin 81 (KRT81)

kl088Hu01Dickkopf相关蛋白4(DKK4)多克隆抗体Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4)

kl088Mu01Dickkopf相关蛋白4(DKK4)多克隆抗体Polyclonal Antibody to Dickkopf Related Protein 4 (DKK4)

kl116Hu01Clock同源物(CLOCK)多克隆抗体Polyclonal Antibody to Clock Homolog (CLOCK)

kl166Hu01Bcl2样蛋白11(BCL2L11)多克隆抗体Polyclonal Antibody to Bcl2 Like Protein 11 (BCL2L11)