Quantity size:
0.2ml
Concentration:
1mg/ml ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF6 plays a role in protein trafficking near the plasma membrane, including receptor recycling, cell adhesion and cell migration. ARF6 colocalizes with the ARF guanine nucleotide-exchange protein ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体(GEP) BRAG2, also designated GEP100. BRAG2 is ubiquitously expressed as two isoforms, BRAG2a and BRAG2b, which can cycle between the cytoplasm and the nucleus. BRAG2, via its interaction with ARF6, is involved in the regulation of cell adhesion by controlling Integrin ∫1 endocytosis and E-cadherin redistribution. BRAG2 has also been shown to bind directly to Tyr1068/1086-phosphorylated EGFR to activate ARF6, which induces tumor invasion in MCF7 cells. Therefore, BRAG2 may contribute to the metastasis and malignancy of some breast cancer cells.
ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体Also known as:
ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARF GEP100; ARFGEP100; BRAG2; Brefeldin A resistant ARF GEF2; Brefeldin-resistant Arf-GEF 2 protein; GEP100; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1; IQEC1_HUMAN; Iqsec1; Kiaa0763.
Specificity:
●
Rabbit Polyclonal IgG,ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体 affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, .
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Immunogen: KLH conjugated synthetic peptide derived from human GEP100.
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Predicted Molecular Weight: 108kDa.
ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
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企业名称
上海康朗生物科技有限公司
企业信息已认证
企业类型
信用代码
310112001510759
成立日期
2015-05-29
注册资本
100
经营范围
从事生物科技技术领域内技术开发、技术咨询、技术服务、技术转让,实验分析仪器、化工产品及原料(除危险化学品、监控化学品、烟花爆竹、民用爆竹物品、易制毒化学品)、仪器仪表、环保设备、酒店用品、皮革制品、床上用品、电子产品的销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海康朗生物科技有限公司
公司地址
上海市闵行区闵北路88弄1-30号第22栋BV145室
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