G蛋白偶联受体17抗体

Quantity size:

0.2ml

Concentration:

1mg/ml G蛋白偶联受体17抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

G protein-coupled receptor 17, GPR17, also known as uracil nucleotide/cysteinyl leukotriene receptor or P2Y-like receptor (P2YL), is a 367 amino acid member of the G-protein coupled receptor 1 family of proteins. While GPR17 is expressed in kidney, heart and umbilical vein endothelial cells, it is expressed in the highest levels in the brain. Upon brain injury,G蛋白偶联受体17抗体 the extracellular concentrations of nucleotides and cysteinyl leukotrienes (CysLTs), two families of endogenous signaling molecules, increase significantly at the site of damage. In some neurons, GPR17, a membrane receptor for uracil nucleotide and CysLTs, is upregulated as well,G蛋白偶联受体17抗体 infiltrating the lesioned area. GPR17 is thought to play a role in mediating neuronal death, remodeling brain circuitries by microglia and initiating remyelination in damaged neurons. Two named isoforms of GPR17 exist as a result of alternative splicing events.

Also known as:

DKFZp686M18273; G protein coupled receptor 17; G-protein coupled receptor 17; GPR 17; Gpr17; GPR17_HUMAN; P2Y like receptor; P2Y-like receptor; Probable P2Y purinoceptor GPR 17; Probable P2Y purinoceptor GPR17; R12; UDP/CysLT receptor; Uracil nucleotide/cysteinyl G蛋白偶联受体17抗体leukotriene receptor; GPCR GPR17.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, .

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Immunogen: KLH conjugated synthetic peptide derived from human G protei.

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G蛋白偶联受体17抗体Predicted Molecular Weight: 41kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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