鸟嘌呤核苷酸交换因子FARP2抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 鸟嘌呤核苷酸交换因子FARP2抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

FARP2 is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a鸟嘌呤核苷酸交换因子FARP2抗体 Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.

鸟嘌呤核苷酸交换因子FARP2抗体Also known as:

FARP 2; FERM; FGD1 related Cdc42 GEF; FIR; FRG; KIAA0793; PLEKHC3; RhoGEF and pleckstrin domain protein 2; FARP2_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, 鸟嘌呤核苷酸交换因子FARP2抗体affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Horse, .

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Immunogen: KLH conjugated synthetic peptide derived from human FARP2 (6.

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Predicted Molecular Weight: 120kDa.

鸟嘌呤核苷酸交换因子FARP2抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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