F-box蛋白家族FBXO11抗体

Quantity size:

0.2ml

Concentration:

1mg/mlF-box蛋白家族FBXO11抗体   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, F-box蛋白家族FBXO11抗体signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I?B-? and ∫-catenin, for proteasomal degradation. FBXO11 (F-box only protein 11), also known as VIT1 (Vitiligo-associated protein 1), F-box蛋白家族FBXO11抗体is a 927 amino acid nuclear protein that contains one UBR-type zinc finger, one F-box domain and 19 PbH1 repeats. Involved in protein ubiquitination, FBXO11 functions as a substrate recognition component of the SCF complex and is thought to bind to and inhibit the transcriptional activity of p53. Reduced expression of FBXO11 is associated with vitiligo, a disease characterized by progressive skin depigmentation. Multiple isoforms of FBXO11 exist due to alternative splicing events.

F-box蛋白家族FBXO11抗体Also known as:

F box protein 11; F-box only protein 11; FBX11; FBX11_HUMAN; Fbxo11; PRMT9; VIT-1; VIT1; Vitiligo associated protein VIT 1; Vitiligo-associated protein 1.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated synthetic peptide derived from hu FBXO11.

F-box蛋白家族FBXO11抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:50-200   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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