FK506结合蛋白38抗体

Quantity size:

0.2ml

Concentration:

1mg/ml FK506结合蛋白38抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferesFK506结合蛋白38抗体   with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. 
Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.
FK506结合蛋白38抗体  Tissue specificity: Widely expressed. Highest levels seen in the brain.

Also known as:

38 kDa FK 506 binding protein homolog; 38 kDa FK506-binding protein; 38 kDa FKBP; 38kDa antibody FK506 binding protein 8; FK506 binding protein 8, 38kDa; FK506 binding protein, 38kDa; FK506-binding protein 8FK506结合蛋白38抗体  ; FKBP 38; FKBP-38; FKBP-8; FKBP8; FKBP8_HUMAN; FKBPR38; hFKBP38; Peptidyl-prolyl cis-trans isomerase FKBP8; PPIase FKBP8; Rotamase; Sam11.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, .

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Immunogen: KLH conjugated synthetic peptide derived from human FKBP38.

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Predicted Molecular Weight: 46kDa.

FK506结合蛋白38抗体  Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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