FAS凋亡抑制分子2

Quantity size:

0.2ml

Concentration:

1mg/ml FAS凋亡抑制分子2  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein FAS凋亡抑制分子2that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD tFAS凋亡抑制分子2o Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.

FAS凋亡抑制分子2Also known as:

FAIM 2; Fas apoptotic inhibitory molecule 2; LFG; Lifeguard; Neural membrane protein 35; NGP 35; NGP35; NMP 35; NMP35; Protein lifeguard; TMBIM 2; TMBIM2; Transmembrane BAX inhibitor motif containing 2; Transmembrane BAX inhibitor motif containing protein 2; LFG2_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, Monkey, .

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Immunogen: KLH conjugated synthetic peptide derived from human FAIM2.

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Predicted Molecular Weight: 35kDa.

FAS凋亡抑制分子2Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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