CD44抗体

?CD44抗体Quantity size:

0.2ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

CD44 is the receptor for hyaluronic acid (HA). It mediates cell to cell and cell matrix interactions through its affinity for HA. Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. High protein heterogeneity due to several alternative splicing and post translational modification events. CD44抗体CD44R represents a heterogeneous group of CD44 variant isoforms expressed constitutively in epithelial cells and monocyte lineage cells and can be upregulated in activated leukocytes. CD44R, and in particular CD44v6 containing isoforms, may be involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to sites of inflammation. CD44v6 containing isoforms may be involved in tumor metastasis.

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellularCD44抗体 functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq].

Also known as:

Homing Cell Adhesion Molecule; Epican; Heparan sulfate proteoglycan; Hyaluronate receptor; Antigen gp90 homing receptor; CD44; CD44 antigen; CD44 antigen homing function and Indian blood group system; CD44抗体CD44 molecule; CD44 molecule Indian blood group; CD44R; CDw44; CDW44 antigen; Chondroitin sulfate proteoglycan 8; CSPG8; ECMR III; ECMRIII; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HCELL; Hematopoietic cell E and L selectin ligand; Hermes antigen; Homing function and Indian blood group system; HUTCH I; IN ; INLU related p80 glycoprotein; LHR; MC56; MDU2; MDU3; MGC10468; MIC4; MUTCH I; MUTCHI; PGP 1; Phagocytic glycoprotein I; CD44_RAT.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, .

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Immunogen: KLH conjugated synthetic peptide derived from rat CD44v6.

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CD44抗体Predicted Molecular Weight: 53kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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