周期素依赖性激酶1抗体

?周期素依赖性激酶1抗体Quantity size:

0.2ml

Concentration:

1mg/ml   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B.周期素依赖性激酶1抗体 The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases 周期素依赖性激酶1抗体while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.

Also known as:

周期素依赖性激酶1抗体Cdc 2; Cdc2; CDK 1; CDK1; Cell division control protein 2; Cell division control protein 2 homolog; PSTAIR; Cell division cycle 2 G1 to S and G2 to M; Cell Divsion Cycle 2 Protein; Cyclin Dependent Kinase 1; DKFZp686L20222; MGC111195; p34 Cdk1; p34 Protein Kinase.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Bovine, .

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Immunogen: KLH conjugated synthetic peptide derived from human CDK1 C-terminus.

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周期素依赖性激酶1抗体Predicted Molecular Weight: 34kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:10-200  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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