磷酸化β抑制蛋白1抗体Quantity size:
0.1ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors 磷酸化β抑制蛋白1抗体(GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 磷酸化β抑制蛋白1抗体412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
Also known as:
beta Arrestin 1 (phospho S412); p-beta Arrestin 1 (phospho S412); ARB 1; ARB1; 磷酸化β抑制蛋白1抗体ARR 1; ARR1; ARRB 1; ARRB1; Arrestin beta 1.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Cow, .
●
Immunogen: KLH conjugated Synthesised phosphopeptide derived from human beta-Arrestin 1 around the phosphorylation site of Ser412.
●
Predicted Molecular Weight: 45kDa.
磷酸化β抑制蛋白1抗体Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
kl251Hu01Adropin蛋白(AD)多克隆抗体Polyclonal Antibody to Adropin (AD)
kl280Hu01食道癌相关基因4(ECRG4)多克隆抗体Polyclonal Antibody to Esophageal Cancer Related Gene 4 (ECRG4)
kl341Hu01CD200受体1(CD200R1)多克隆抗体Polyclonal Antibody to CD200 Receptor 1 (CD200R1)
kl468Hu01血管生成素样蛋白6(ANGPTL6)多克隆抗体Polyclonal Antibody to Angiopoietin Like Protein 6 (ANGPTL6)
kl468Ra01血管生成素样蛋白6(ANGPTL6)多克隆抗体Polyclonal Antibody to Angiopoietin Like Protein 6 (ANGPTL6)
kl557Hu01补体应答基因32(RGC32)多克隆抗体Polyclonal Antibody to Response Gene To Complement 32 (RGC32)
kl576Hu01含Ⅲ型纤连蛋白域蛋白5(FNDC5)多克隆抗体Polyclonal Antibody to Fibronectin Type III Domain Containing Protein 5 (FNDC5)
kl637Hu01Pim-3原癌基因(PIM3)多克隆抗体Polyclonal Antibody to Pim-3 Oncogene (PIM3)
kl690Hu01含胶原三螺旋重复蛋白1(CTHRC1)多克隆抗体Polyclonal Antibody to Collagen Triple Helix Repeat Containing Protein 1 (CTHRC1)
kl729Hu01ⅫB组磷脂酶A2(PLA2G12B)多克隆抗体Polyclonal Antibody to Phospholikle A2, Group XIIB (PLA2G12B)
磷酸化β抑制蛋白1抗体信息由上海康朗生物科技有限公司为您提供,如您想了解更多关于磷酸化β抑制蛋白1抗体报价、型号、参数等信息,欢迎来电或留言咨询。除供应磷酸化β抑制蛋白1抗体外,上海康朗生物科技有限公司还可为您提供β-抑制蛋白2抗体/β休止蛋白2/β-arrestin抗体、β-抑制蛋白1/2抗体、人胸腺嘧啶核苷磷酸化酶检测试剂盒等产品,公司有专业的客户服务团队,是您值得信赖的合作伙伴。