血管紧张素Ⅱ受体1抗体Quantity size:
0.2ml
Concentration:
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2,血管紧张素Ⅱ受体1抗体 most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLC?is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event.血管紧张素Ⅱ受体1抗体 Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites.
Also known as:
血管紧张素Ⅱ受体1抗体AG2S; Agtr 1; Agtr1; AGTR1_HUMAN; Agtr1a; AGTR1B; Ang II; Angiotensin II receptor type 1; Angiotensin II type 1 receptor; Angiotensin II type-1 receptor; Angiotensin receptor 1; Angiotensin receptor 1B; AT 1B; AT 1r; AT-1B; AT-1r; AT1; At1a; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor; Type 1B angiotensin II receptor; Type-1 angiotensin II receptor.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, .
●
Immunogen: KLH conjugated synthetic peptide derived from human AT2R C-terminus.
●
Predicted Molecular Weight: 41kDa.
血管紧张素Ⅱ受体1抗体Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
kl477Hu01RIO激酶1(RIOK1)多克隆抗体Polyclonal Antibody to RIO Kinase 1 (RIOK1)
kl723Hu01含MANSC域蛋白1(MANSC1)多克隆抗体Polyclonal Antibody to MANSC Domain Containing Protein 1 (MANSC1)
kl952Hu01NADH脱氢酶5(ND5)多克隆抗体Polyclonal Antibody to NADH Dehydrogenase 5 (ND5)
kl618Hu01甘露糖受体C1样蛋白1(MRC1)多克隆抗体Polyclonal Antibody to Mannose Receptor C Type 1 Like Protein 1(MRC1)
kl642Hu01核糖核酸酶A12(RNASE12)多克隆抗体Polyclonal Antibody to Ribonuclease A12 (RNASE12)
kl653Hu01CD200受体2(CD200R2)多克隆抗体Polyclonal Antibody to CD200 Receptor 2 (CD200R2)
kl758Mu01糖化溶酶体膜蛋白(GLMP)多克隆抗体Polyclonal Antibody to Glycosylated Lysosomal Membrane Protein (GLMP)
kl844Hu01血管紧张素1-9(Ang1-9)多克隆抗体Polyclonal Antibody to Angiotensin 1-9 (Ang1-9)
kl207Hu01半乳糖凝集素9B(GAL9B)多克隆抗体Polyclonal Antibody to Galectin 9B (GAL9B)
kl491Hu01含动力蛋白重链域蛋白1(DNHD1)多克隆抗体Polyclonal Antibody to Dynein Heavy Chain Domain Containing Protein 1 (DNHD1)
kl122Hu01序列相似家族132成员A(FAM132A)多克隆抗体Polyclonal Antibody to Family With Sequence Similarity 132, Member A (FAM132A)
kl236Hu01半乳糖凝集素9C(GAL9C)多克隆抗体Polyclonal Antibody to Galectin 9C (GAL9C)
kl381Hu01胃泌酸调节素(OXM)多克隆抗体Polyclonal Antibody to Oxyntomodulin (OXM)
kl002Bo01白细胞激活黏附因子(ALCAM)多克隆抗体Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM)
kl002Hu01白细胞激活黏附因子(ALCAM)多克隆抗体Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM)
kl002Mu01白细胞激活黏附因子(ALCAM)多克隆抗体Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM)
kl002Ra01白细胞激活黏附因子(ALCAM)多克隆抗体Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM)
kl002Rb51白细胞激活黏附因子(ALCAM)多克隆抗体Polyclonal Antibody to Activated Leukocyte Cell Adhesion Molecule (ALCAM)
kl004Bo01血管紧张素转化酶(ACE)多克隆抗体Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE)
kl004Hu01血管紧张素转化酶(ACE)多克隆抗体Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE)
kl004Mu01血管紧张素转化酶(ACE)多克隆抗体Polyclonal Antibody to Angiotensin I Converting Enzyme (ACE)
更多
企业名称
上海康朗生物科技有限公司
企业信息已认证
企业类型
信用代码
310112001510759
成立日期
2015-05-29
注册资本
100
经营范围
从事生物科技技术领域内技术开发、技术咨询、技术服务、技术转让,实验分析仪器、化工产品及原料(除危险化学品、监控化学品、烟花爆竹、民用爆竹物品、易制毒化学品)、仪器仪表、环保设备、酒店用品、皮革制品、床上用品、电子产品的销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海康朗生物科技有限公司
公司地址
上海市闵行区闵北路88弄1-30号第22栋BV145室
客服电话