抗磷酸化信号转导和转录激活因子3抗体

抗磷酸化信号转导和转录激活因子3抗体产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

抗磷酸化信号转导和转录激活因子3抗体产品介绍

    转录调节因子（Transcriptin Regulators） 

    STATs (signal transducers and activators of transcription) were originally discovered as two proteins (STAT1 and STAT2) which were involved in interferon alpha (IFN alpha) and IFN gamma signal transduction. Since then, several additional STAT proteins have been identified (STAT3, 4, 5a, 5b, and 6). STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases (Janus Kinases 1, 2, and 3). For maximum activation of these proteins, phosphorylation at specific tyrosine and serine residues may be required in STAT1 alpha, 3, 4, and 5.
    Specific functions of the various members of the STAT family are poorly understood. STAT3 has been shown to be activated by IFN alpha but not IFN beta. The transcription factors associated with STAT3 are cJun and cyclic AMP responsive enhancer binding protein (CREB). Deletion of the STAT3 gene in knock out mice was lethal at the early embryonic stage. 
    STAT1 and STAT2 are induced by IFN alpha and forn 1, a heterodimer which is part of the ISGF transcription factor complex. The STAT3 protein is expressed in most cell types and is activated by multiple cytokines and growth factors including: IFNa, IL10, IL6, IL11, IL12, IL2, EGF, among others. STAT3 beta appears to be activated by both EGF and IL6, but STAT3 alpha is only activated by EGF. STAT3 binds to DNA as either a homodimer or as a heterodimer with STAT1. STAT3 interacts with the APRE acute phase response element) and SIE (csis inducible element). STAT4, predominantly expressed in testis and myeloid cells, is activated by ILl2. STAT5 is activated by prolactin and IL3. STAT6 participates in signaling pathways mediated by IL4.

    Also known as: 
    Acute Phase Response Factor; APRF; DNA binding protein APRF; FLJ20882; MGC16063; Signal Transductor and Activator of Transcription 3; STAT 3

抗磷酸化信号转导和转录激活因子3抗体

hz-6009R GAS8  生长停滞特异性蛋白8抗体

hz-6010R GTPBP4/CRFG  GTP结合蛋白4抗体（慢性肾功能衰竭蛋白）

hz-6011R HACE1  E3泛素蛋白连接酶HACE1抗体

hz-6014R SMARCA6/HELLS  淋巴特异性解旋酶抗体

hz-6015R SMARCA1/SNF2L  解旋酶SNF2L抗体

hz-6017R ACBD6  酰基辅酶A结合结构域蛋白6抗体

hz-6018R ACVR1B/ALK4  激活素A受体1B抗体

hz-6019R ACY1/Aminoacylase 1  氨基酰化酶1抗体

hz-6020R ACVRL1/ALK1  激活素受体样激酶1抗体

hz-6021R ASAH2  酰基鞘氨醇脱酰酶2抗体

hz-6022R ASAM/ACAM  脂肪细胞特异性粘附分子抗体

hz-6024R CARPX/CA10  碳酸酐酶相关蛋白抗体（脑蛋白15）

hz-6025R CA12  碳酸酐酶12抗体

hz-6028R IGFR3/CD16  FC段γ受体3/免疫球蛋白G Fc段受体III抗体

hz-6030R CD200/MOX1  膜糖蛋白CD200抗体

hz-6032R CD66c/CEACAM6  癌胚抗原相关细胞粘附分子抗体

hz-6034R CPA1/Carboxypeptidase A  胰羧肽酶A1抗体

hz-6035R CPA2/Carboxypeptidase A2  羧肽酶A2抗体

hz-6036R CPB1/Carboxypeptidase B1  胰羧肽酶B1抗体

hz-6037R CPEB1  细胞质多聚腺苷酸结合蛋白1抗体

hz-6042R Cystatin E/M  半胱氨酸蛋白酶抑制剂6抗体

hz-6038R CRABP2  细胞维甲酸结合蛋白2抗体

hz-6039R CST7/Cystatin F  半胱氨酸蛋白酶抑制剂7抗体

hz-6043R NBL1/DAND1  神经母细胞瘤抑瘤蛋白1抗体

hz-6044R DLL4/Delta 4  Notch信号通路Delta样配体4抗体

hz-6045R DPP2  溶酶体丝氨酸蛋白酶DPP2抗体

hz-6050R FSTL1/FRP  卵泡相关蛋白1

hz-6051R HPGD/PGDH1/Prostaglandin dhzydrogenase 1  前列腺素脱氢酶1抗体

hz-6052R HPRG/HRG  组氨酸富含脯氨酸糖蛋白抗体

hz-6053R Hhzopexin/HPX  糖蛋白β-1B抗体

hz-6055R LRPAP1/MRAP  脂蛋白受体相关蛋白抗体（低密度脂蛋白相关蛋白的相关蛋白1）

hz-6056R MEP1A/Meprin alpha/PPHA  苯甲酸肽水解酶抗体

hz-6057R METTL11A  甲基化样蛋白11抗体（N端）

hz-6058R Nicastrin  老年性痴呆蛋白APH2抗体