磷酸化APP(Tyr757)淀粉样肽前体蛋白抗体

磷酸化APP(Tyr757)淀粉样肽前体蛋白抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

磷酸化APP(Tyr757)淀粉样肽前体蛋白抗体产品介绍

    Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. Immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. APP is expressed in the brain, kidney, heart and spleen of fetal tissues; it is induced during neuronal differentiation. In adult brain, highest expression of APP is found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Defects in APP are a cause of autosomal dominant Alzheimer's disease (AD).
    Phosphorylation of APP at Tyr757 and 762 is important for MAPK8IP1, APBA1, shcA/shcC and DAB1 binding. Binding interactions regulated by phosphorylation determine the localisation and the function of APP. Therefore Amyloid Precursor Protein (phospho Y757) antibody will be a useful tool in tracing the processing, distribution and interaction of APP.
    mol wt:85kDa 
    Other Aliases: 
    A4 amyloid protein; A4; AAA; ABETA; ABPP; AD 1; AD1; Alzheimer disease 1; Alzheimer disease; Alzheimer's disease amyloid protein; Amyloid beta (A4) precursor protein; Amyloid beta A4 protein; Amyloid beta A4 protein precursor isoform b; Amyloid beta A4 protein precursor isoform c; Amyloid beta A4 protein precursor isoform a; Amyloid beta A4 protein precursor isoform b; Amyloid beta A4 protein precursor isoform c; Amyloid beta protein; Amyloid beta-peptide; Amyloid of aging and alzheimer disease; APP; APP I ; APPI; Beta amyloid peptide; Cerebral vascular amyloid peptide; CTFgamma; CVAP; Human mRNA for amyloid A4 precursor of Alzheimer's disease; PN 2; PN II; PN2; PreA4; Protease nexin II

磷酸化APP(Tyr757)淀粉样肽前体蛋白抗体

hz-2247R AHA3  AHA3抗体（拟南芥）

hz-4171R Angiomotin  血管抑素结合蛋白抗体

hz-4193R HIP4/CBS  丝氨酸羧甲半胱氨酸合成酶抗体

hz-1004R ACE2  血管紧张素转换酶2抗体

hz-0203R ACEI  血管紧张素1转换酶抑制剂抗体

hz-2745R Acetyl CoA Carboxylase  乙酰辅酶A羧化酶抗体

hz-3036R Phospho-Acetyl CoA Carboxylase(Ser79)  磷酸化乙酰辅酶A羧化酶抗体

hz-1962R ACD  肾上腺皮质发育异常蛋白抗体

hz-2511R ACHE/Acetylcholinesterase  乙酰胆碱酶抗体

hz-0120R Acinus  Acinus抗体

hz-3001R phospho-Acinus(Ser1180)  磷酸化腺泡Acinus蛋白抗体

hz-1227R Ack1  醋酸激酶1抗体

hz-3038R Phospho-Ack1(Tyr859/860)  磷酸化Ack1抗体

hz-3045R Phospho-Ack1(Tyr284)  磷酸化Ack1抗体

hz-3046R Phospho-Ack1(Tyr326)  磷酸化Ack1抗体

hz-5022R ACSL1  长链脂肪酸辅酶A连接酶1/2抗体

hz-0443R ACTH (1-39)  促肾上腺皮质激素(1-39)抗体

hz-3678R Phospho-MKP1 (Ser318)  磷酸化丝裂原活化蛋白激酶磷酸酶1抗体

hz-0442R ACTH (18-39)  促肾上腺皮质激素ACTH(18-39)抗体

hz-0004R ACTH (7-23)  促肾上腺皮质激素ACTH (7-23)抗体

hz-0189R Actin α/alpha-SMA  肌动蛋白α(α-SMA)抗体

hz-4178R Sarcomeric Alpha Actinin/ACTN2  α横纹肌辅肌动蛋白/α-SCA抗体

hz-1741R alpha Actinin 4  α-辅肌动蛋白4抗体

hz-1571R F-Actin  纤维状肌动蛋白抗体

hz-5031R ACOT8  酰基辅酶A硫酯酶8

hz-5032R Agpat2  溶血磷脂酸酰基转移酶β抗体

hz-5033R AGPAT4  溶血磷脂酸酰基转移酶D抗体

hz-5633R phospho-SYT1(Thr202)  磷酸化突触结合蛋白1抗体

hz-4172R Synaptotagmin 1/SYT1  突触结合蛋白1抗体

hz-5629R phospho-SYT1(Ser309)  磷酸化突触结合蛋白1抗体

hz-5630R phospho-SYN1(Ser549)  磷酸化神经突触素1抗体

hz-5631R phospho-SYN1(Ser603)   磷酸化神经突触素1抗体

hz-5632R phospho-SYN1(Ser62+Ser67)  磷酸化神经突触素1抗体

hz-0046R AD7c-NTP  神经丝蛋白抗体

hz-5858R ADAMTS2  整合素样金属蛋白酶与凝血酶2型抗体