脑胚胎锌指样蛋白1抗体

英文名称    FEZ1    

中文名称    脑胚胎锌指样蛋白1抗体    

别    名    Fasciculation and elongation protein zeta 1; Fasciculation and elongation protein zeta-1; Fez 1; Fez; Fez-like zinc finger protein; FEZ1; FEZ1_HUMAN; Fezl; Forebrain embryonic zinc-finger like protein; Zpf312; Zygin 1; Zygin I; Zygin-1; Zygin1; ZyginI.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  神经生物学  细胞周期蛋白  细胞分化  锌指蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）脑胚胎锌指样蛋白1抗体 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    45kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human FEZ1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

脑胚胎锌指样蛋白1抗体产品介绍    background:

Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumors of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase.

Function:
May be involved in axonal outgrowth as component of thenetwork of molecules that regulate cellular morphology and axonguidance machinery. Able to restore partial locomotion and axonalfasciculation to C.elegans unc-76 mutants in germlinetransformation experiments. May participate in the transport ofmitochondria and other cargos along microtubules.

Subunit:
Homodimer; difulfide-linked. May form heterodimers withFEZ2. Interacts with the NH2-terminal variable region (V1) of PKCzeta and weakly with that of PKC epsilon (By similarity). Interactswith UBE4B. Interacts with SAP30L. Interacts with SCOC and ULK1;SCOC interferes with ULK1-binding to FEZ1. Directly interacts withSCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAGduring amino acid starvation.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Cellmembrane (By similarity). Note=Co-localizes with both, alpha- andgamma-tubulin. Translocated from the plasma membrane to thecytoplasm by activation of the PKC zeta (By similarity).

Tissue Specificity:
Mainly expressed in brain.

Post-translational modifications:
Phosphorylated by protein kinase C zeta; which enhancesinteraction with UBE4B and polyubiquitination.
Polyubiquitinated in a UBE4B-dependent manner; which does notlead to proteasomal degradation and may be important for neurogenicactivity. Polyubiquitin linkage seems to be mainly through Lys-26.

Similarity:
Belongs to the zygin family.    

脑胚胎锌指样蛋白1抗体

hz-5982R CDKN2D/p19 INK4d  细胞周期蛋白依赖性激酶抑制剂2D抗体

hz-4272R CHFR  泛素连接酶蛋白CHFR抗体

hz-4207R CHMP1A  染色质修饰蛋白1A抗体

hz-2495R CD30/TNFRSF8  CD30抗体

hz-0468R CD31/PECAM-1  血小板内皮细胞黏附分子-1抗体

hz-0195R CD31/PECAM-1  血小板内皮细胞黏附分子-1抗体

hz-2042R CD33/Siglec-3  CD33抗体

hz-1514R CD33/Siglec-3  CD33抗体

hz-2704R CD33L/OBBP1  CD33L抗体

hzm-2079M Cecropin monoclonal  杀菌肽/天蚕抗菌肽单克隆抗体

hz-4276R ELAC2  遗传性前列腺癌蛋白2抗体

hz-0646R CD34  CD34抗体

hz-2038R CD34  CD34抗体

hz-0979R CD38  CD38抗体

hz-0980R CD38  CD38抗体

hz-4277R ENPP7  碱性鞘磷脂酶7抗体

hz-2596R CR1/CD35  Ⅰ型补体受体抗体（C3b/C4b受体抗体）

hz-4274R DBC2  乳腺癌基因删除蛋白2抗体

hz-4278R FAT/CDHF7/FAT1  钙粘蛋白家族成员7抗体

hz-1100R CD36/PAS-4  CD36抗体

hz-4279R GAS7/Growth Arrest Specific Protein 7  生长休止特定蛋白7抗体

hz-4275R EB3  微管相关蛋白EB家族3抗体

hz-0766R CD4  CD4抗体

hz-0647R CD4  CD4抗体

hz-1520R CD7  CD7抗体

hz-0648R CD8  CD8抗体

hz-4914R CD8B  CD8β链（CD8-β）抗体

hz-4602R CD8/CD8-β  CD8抗体

hz-2489R CD9/MRP-1  CD9蛋白抗体

hz-5711R CCDC106  卷曲螺旋结构域蛋白106抗体

hz-2929R CD40/TNFRSF5  肿瘤坏死因子受体超家族成员5抗体

hz-1286R CD40L  CD40L抗体