EDEM1蛋白抗体

英文名称    EDEM1    

中文名称    EDEM1蛋白抗体    

别    名    EDEM 1; EDEM1_HUMAN; EDEM; Endoplasmic reticulum degradation enhancing alpha mannosidase like protein; ER degradation enhancer, mannosidase alpha like 1; ER degradation enhancing alpha mannosidase like 1; KIAA0212.    

说 明 书    0.2ml      

研究领域    细胞生物  免疫学  信号转导      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 EDEM1蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    74kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human ECT2 around the phosphorylation site of Thr790    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

EDEM1蛋白抗体产品介绍    background:

Proteins expressed in the endoplasmic reticulum (ER) are subjected to a tight quality control. Terminally misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM (ER degradation-enhancing alpha-mannosidase-like) protein is a type II membrane protein that localizes to the ER and is directly involved in ERAD. EDEM targets misfolded glycoproteins for degradation in an N-glycan-dependent manner and extracts misfolded glycoproteins from the calnexin cycle. The human EDEM gene maps to chromosome 3p.

Function:
EDEM1 is directly involved in ER associated degradation (ERAD), and targets misfolded glycoproteins for degradation in an N glycan dependent manner. It lacks mannosidase activity. EDEM1 belongs to the glycosyl hydrolase 47 family.

Subunit:
Interacts with DNAJC10 (By similarity). Interacts with DERL2 and DERL3. Binds to SEL1L.

Subcellular Location:
Endoplasmic reticulum membrane.

Similarity:
Belongs to the glycosyl hydrolase 47 family.

Gene ID:
9695

Database links:

Entrez Gene: 9695 Human

Entrez Gene: 192193 Mouse

SwissProt: Q92611 Human

SwissProt: Q925U4 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

EDEM1蛋白抗体

E-69-48/96 Anti-TM  甲状腺微粒体抗体(TM抗体)

E-42-48/96 AFP  甲胎蛋白定量(一/二步夹心法)　

E-43-48/96 AFP  甲胎蛋白定性

E-45-48/96 CEA  癌胚抗原定量　

E-80-48/96 CEA  癌胚抗原定性(一/二步夹心法)

E-47-48/96 Ferritin  铁蛋白

E-49-48/96 Beta2-MG  β2-微球蛋白

E-51-48/96 PSA  前列腺特异性抗原

E-92-48/96 CA50  上皮类癌相关抗原

E-93-48/96 CA125  卵巢癌相关抗原

E-94-48/96 CA153  乳腺癌相关抗原

E-95-48/96 CA199  胰腺癌相关抗原

A-02-1 CMV  巨细胞病毒 IgG(间接法二步法)

A-01-1 CMV  巨细胞病毒 IgM(间接法二步法)

A-35 CMV  巨细胞病毒 IgM(捕获法一步法)

A-42 CMV IgM  巨细胞病毒 IgM(捕获法二步法)

A-04-1 RV  风疹胞病毒 IgG(间接法二步法)

A-03-1 RV IgM  风疹胞病毒 IgM(间接法二步法)

A-34 RV IgM  风疹病毒 IgM(捕获法一步法)

hz-1011 Mouse Lactate Dhzydrogenase,LDH ELISA Kit  小鼠乳酸脱氢酶

hz-1011 MHB(Rat Methhzoglobin,MHB) ELISA Kit  大鼠高铁血红蛋白

hz-1011 Fc GammaR I /CD64(Human Receptor I for the Fc region of immunoglobulin G,Fc GammaR I ) ELISA Kit  人免疫球蛋白G Fc段受体Ⅰ

EF-1011 C3 ELISA Kit  鲑鱼补体蛋白3

EA-1011 Alpha2-AP (Rabbit Alpha2-Antiplasmin) ELISA Kit  兔子α2抗纤溶酶

A-43 RV IgM  风疹胞病毒 IgM(捕获法二步法)

A-16-1 TOXO IgG  弓形虫抗体 IgG(间接法二步法)

A-15-1 TOXO IgM  弓形虫抗体 IgM(间接法二步法)

A-33 TOXO IgM  弓形虫抗体 IgM(捕获法一步法)

A-44 TOXO IgM  弓形虫抗体 IgM(捕获法二步法)

A-40-1 HSV- I IgG  单纯疱疹Ⅰ型病毒 IgG(间接法二步法)

A-18-1 HSV- I IgM  单纯疱疹Ⅰ型病毒 IgM(间接法二步法)

A-36 HSV- I IgM  单纯疱疹Ⅰ型病毒 IgM（捕获法一步法）

A-45 HSV- I IgM  单纯疱疹Ⅰ型病毒 IgM（捕获法二步法）

A-41-1 HSV- II IgG  单纯疱疹Ⅱ型病毒 IgG(间接法二步法)