早期B淋巴细胞因子2抗体

英文名称    EBF2    

中文名称    早期B淋巴细胞因子2抗体    

别    名    COE 2; COE2; Collier Olf and EBF 2; Early B cell factor 2; EBF 2; FLJ11500; Metencephalon mesencephalnon olfactory transcription factor 1; O/E 3; O/E3; OE 3; OE3; OLF 1/EBF like 3; Transcription factor COE2; COE2_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  神经生物学  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 早期B淋巴细胞因子2抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    63kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human EBF2 (331-400aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

早期B淋巴细胞因子2抗体产品介绍    background:

Early B-cell factor 2 is a 575 amino acid protein belonging to the COE family of proteins, whose members are all helix-loop-helix transcription factors. EBF2 is a transcription factor which, in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, activates the decoy receptor for RANKL, OPG, in osteoblasts. OPG, in turn, regulates osteoclast differentiation. Lack of EBF2 has been found to cause a small defect in the terminal differentiation of osteoblasts, along with reduced bone mass and an increase in osteoclasts. Localized to the nucleus, EBF2 forms a homodimer or a heterodimer with a related family member.

Function:
EBF2 (Early B-cell factor 2) belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors. In osteoblasts it activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. EBF2 acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. It recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.

Subunit:
Forms either a homodimer or a heterodimer with a relatedfamily member

Subcellular Location:
Nuclear

Similarity:
Belongs to the COE family.
Contains 1 IPT/TIG domain.     

早期B淋巴细胞因子2抗体

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hz-2311R Classical swine fever virus  抗猪瘟病毒抗体

hz-0532R PHD3  脯氨酸羟化酶抗体

hz-3686R PHD2  脯氨酸羟化酶2抗体

hz-0024R presenilin 1/PS-1 (NT)  早老素蛋白-1抗体

hz-0025M presenilin 1/PS-1 (CT)  早老素蛋白-1抗体

hz-0024M presenilin 1/PS-1  早老素蛋白-1抗体

hz-3815R presenilin 2/PS-2  早老素蛋白-2抗体

hz-3866R Protor-1  乳腺癌抑制基因Protor1抗体

hz-5105R PRS3/PRE7  蛋白酶体复合物C5抗体

hzm-1625M PSA(Pa3)  人前列腺特异性抗原单克隆抗体(包被)

hzm-1626M PSA(PA5)  鼠抗人前列腺特异性抗原单克隆抗体(检测)

hzm-2465M CPSA(C2F9)  复合前列腺特异性抗原单克隆抗体

hz-2899R PMS/FOLH1/PMSA  前列腺特异膜抗原抗体

hz-1879R PSAP/PAP  前列腺酸性磷酸酶抗体

hz-2241R PSAP  鞘脂激活蛋白原抗体

hz-0669R PSCA  前列腺干细胞抗原抗体

hz-2395R Pescadillo  雌激素受体共调节因子抗体

hz-2341R PGF2 α  前列腺素F2a抗体

hz-3538R PSD93  突触后密度蛋白93抗体

hz-3348R Phospho-PSD93 (Tyr340)  磷酸化突触后密度蛋白93抗体

hz-0179R PSD95  突触后密度蛋白95抗体

hz-3349R Phospho-PSD95 (Tyr236/Tyr240)  磷酸化突触后密度蛋白95抗体

hz-2301R PSGL-1/CD162  P选择素糖蛋白配体1抗体

hz-1372R PSMD9  蛋白酶调解因子9抗体

hz-6087R PSMD10/Proteasome 26S S10  蛋白酶调解因子10抗体

hz-2787R LMP2  低分子质量蛋白2抗体

hz-2796R LMP7  低分子量蛋白酶体7抗体

hz-0561R P-selectin/CD62p  P选择素抗体

hz-1036R L-Selectin/CD62L  L选择素抗体

hz-1273R E-Selectin/CD62E  E选择素抗体

hz-1614R Patched/PTCH  Patched/PTCH抗体

hz-1523R CD63/MLA1  黑色素瘤相关抗原抗体