磷酸化驱动蛋白样蛋白1抗体

英文名称    phospho-Eg5(Thr926)    

中文名称    磷酸化驱动蛋白样蛋白1抗体    

别    名    Eg5 (phospho T926); KIF11(phospho T926); TRIP5(phospho T926); p-Eg5(Thr926); p-KIF11(Thr926); p-TRIP5(Thr926); HKSP; KIF11; kinesin family member 11; Kinesin like protein 1; Kinesin like spindle protein HKSP; KNSL1; Thyroid receptor interacting protein 5; TRIP5; KIF11_HUMAN.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    细胞生物  信号转导  细胞骨架  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Chicken, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 磷酸化驱动蛋白样蛋白1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    120kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human Eg5 around the phosphorylation site of Thr926 [GT(p-T)PQ]    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化驱动蛋白样蛋白1抗体产品介绍    background:

Eg5 is a motor protein that belongs to the kinesin-like family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.

Function:
Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.

Subunit:
Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Interacts (via C-terminus) with the kinase NEK6 in both interphase and mitosis.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton, spindle pole.

Post-translational modifications:
Phosphorylated exclusively on serine during S phase, but on both serine and Thr-926 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase). Phosphorylated upon DNA damage, probably by ATM or ATR. 
A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.

Similarity:
Belongs to the kinesin-like protein family. BimC subfamily. 
Contains 1 kinesin-motor domain.

Database links:
UniProtKB/Swiss-Prot: P52732.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷酸化驱动蛋白样蛋白1抗体

HZA228Ra 大鼠抗缪勒管激素(AMH)ELISA试剂盒 ELISA Kit for Anti-Mullerian Hormone (AMH)

HZA685Ra 大鼠CD14分子(CD14)ELISA试剂盒 ELISA Kit for Cluster Of Differentiation 14 (CD14)

HZA680Ra 大鼠棕榈酰化膜蛋白2(MPP2)ELISA试剂盒 ELISA Kit for Membrane Protein, Palmitoylated 2 (MPP2)

HZA681Ra 大鼠乙醇脱氢酶1(ADH1)ELISA试剂盒 ELISA Kit for Alcohol Dehydrogenase 1 (ADH1)

HZB406Ra 大鼠脂多糖结合蛋白(LBP)ELISA试剂盒 ELISA Kit for Lipopolysaccharide Binding Protein (LBP)

HZB472Ra 大鼠碱性磷酸酶(ALP)ELISA试剂盒 ELISA Kit for Alkaline Phosphatase (ALP)

HZB064Ra 大鼠凋亡诱导因子(AIF)ELISA试剂盒 ELISA Kit for Apoptosis Inducing Factor (AIF)

HZA273Ra 大鼠抑制素结合蛋白(INHBP)ELISA试剂盒 ELISA Kit for Inhibin Binding Protein (INHBP)

CEA260Ra 大鼠β2-微球蛋白(β2M)ELISA试剂盒 ELISA Kit for Beta-2-Microglobulin (b2M)

HZB656Ra 大鼠三叶因子3(TFF3)ELISA试剂盒 ELISA Kit for Trefoil Factor 3, Intestinal (TFF3)

HZB119Ra 大鼠金属硫蛋白1(MT1)ELISA试剂盒 ELISA Kit for Metallothionein 1 (MT1)

HZB657Ra 大鼠肉毒碱脂酰转移酶(CACT)ELISA试剂盒 ELISA Kit for Carnitine Acylcarnitine Translocase (CACT)

HZB370Ra 大鼠乳酸脱氢酶A(LDHA)ELISA试剂盒 ELISA Kit for Lactate Dehydrogenase A (LDHA)

HZB671Ra 大鼠AMP激活蛋白激酶β1(PRKAβ1)ELISA试剂盒 ELISA Kit for Protein Kinase, AMP Activated Beta 1 (PRKAb1)

HZB672Ra 大鼠促性腺激素释放激素受体(GnRHR)ELISA试剂盒 ELISA Kit for Gonadotropin Releasing Hormone Receptor (GnRHR)

HZB685Ra 大鼠整合素αM(ITGαM)ELISA试剂盒 ELISA Kit for Integrin Alpha M (ITGaM)

HZB006Ra 大鼠高密度脂蛋白(HDL)ELISA试剂盒 ELISA Kit for High Density Lipoprotein (HDL)

CEB107Ra 大鼠低密度脂蛋白(LDL)ELISA试剂盒 ELISA Kit for Low Density Lipoprotein (LDL)

HZB571Ra 大鼠胸腺激活调节趋化因子(TARC)ELISA试剂盒 ELISA Kit for Thymus Activation Regulated Chemokine (TARC)

HZB700Ra 大鼠白介素17B(IL17B)ELISA试剂盒 ELISA Kit for Interleukin 17B (IL17B)

HZB039Ra 大鼠表面活性物质关联蛋白D(SPD)ELISA试剂盒 ELISA Kit for Surfactant Associated Protein D (SPD)

HZA957Ra 大鼠Ⅰ型前胶原氨基端原肽(PⅠNP)ELISA试剂盒 ELISA Kit for Procollagen I N-Terminal Propeptide (PINP)

HZA095Ra 大鼠巨噬细胞炎性蛋白3α(MIP3α)ELISA试剂盒 ELISA Kit for Macrophage Inflammatory Protein 3 Alpha (MIP3a)

HZA370Ra 大鼠β-血小板球蛋白(βTG)ELISA试剂盒 ELISA Kit for Beta-Thromboglobulin (bTG)

HZB688Ra 大鼠白介素21(IL21)ELISA试剂盒 ELISA Kit for Interleukin 21 (IL21)

HZB180Ra 大鼠簇集蛋白(CLU)ELISA试剂盒 ELISA Kit for Clusterin (CLU)