Emerin蛋白抗体

英文名称    Emerin    

中文名称    Emerin蛋白抗体    

别    名    EDMD; EMD; EMD_HUMAN; Emerin; Emery Dreifuss muscular dystrophy; STA.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  信号转导  细胞骨架      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 Emerin蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    28kDa    

细胞定位    细胞核 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Emerin (1-100aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

Emerin蛋白抗体产品介绍    background:

Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Tissue specificity; Skeletal muscle, heart, colon, testis, ovary and pancreas.

Function:
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.

Subunit:
Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the nuclear inner membrane. Interacts with SUN1 and SUN2. Interacts with ACTB, SPTAN1, F-actin, CTNNB1 and beta-tubulin.

Subcellular Location:
Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.

Tissue Specificity:
Skeletal muscle, heart, colon, testis, ovary and pancreas.

Post-translational modifications:
Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.

DISEASE:
Defects in EMD are the cause of Emery-Dreifuss muscular dystrophy type 1 (EDMD1) [MIM:310300]. A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.

Similarity:
Contains 1 LEM domain.

Database links:
UniProtKB/Swiss-Prot: P50402.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

Emerin蛋白抗体

HZF701Hu 人氧固醇结合蛋白样蛋白8(OSBPL8)ELISA试剂盒 ELISA Kit for Oxysterol Binding Protein Like Protein 8 (OSBPL8) 

HZG107Hu 人衔接因子相关蛋白复合体2μ1(AP2μ1)ELISA试剂盒 ELISA Kit for Adaptor Related Protein Complex 2 Mu 1 (AP2m1) 

HZG462Hu 人5-甲基四氢叶酸高半胱氨酸甲基转移酶(MTR)ELISA试剂盒 ELISA Kit for 5-Methyltetrahydrofolate Homocysteine Methyltransferase (MTR) 

HZH031Hu 人前列腺转谷氨酰胺酶(TGM4)ELISA试剂盒 ELISA Kit for Transglutaminase 4, Prostate (TGM4) 

HZH255Hu 人维甲酸受体应答基因1(RARRES1)ELISA试剂盒 ELISA Kit for Retinoic Acid Receptor Responder 1 (RARRES1) 

HZK066Hu 人四加半LIM域蛋白1(FHL1)ELISA试剂盒 ELISA Kit for Four And A Half LIM Domains Protein 1 (FHL1) 

HZE258Hu 人前胶原赖氨酸-2-酮戊二酸-5-双加氧酶1(PLOD3)ELISA试剂盒 ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) 

HZE431Hu 人溶质载体家族16成员1(SLC16A1)ELISA试剂盒 ELISA Kit for Solute Carrier Family 16, Member 1 (SLC16A1) 

HZA906Hu 人趋化因子C-C-基元受体5(CCR5)ELISA试剂盒 ELISA Kit for Chemokine C-C-Motif Receptor 5 (CCR5) 

HZM449Hu 人Canopy 2同源物(CNPY2)ELISA试剂盒 ELISA Kit for Canopy 2 Homolog (CNPY2) 

HZD421Hu 人肌球蛋白重链8(MYH8)ELISA试剂盒 ELISA Kit for Myosin Heavy Chain 8, Skeletal Muscle, Perinatal (MYH8) 

HZE269Hu 人B-淋巴酪氨酸激酶(BLK)ELISA试剂盒 ELISA Kit for B-Lymphoid Tyrosine Kinase (BLK) 

HZG901Hu 人电压依赖性阴离子通道蛋白1(VDAC1)ELISA试剂盒 ELISA Kit for Voltage Dependent Anion Channel Protein 1 (VDAC1) 

HZB108Hu 人血小板膜糖蛋白Ⅰbα多肽(GP1Ba)ELISA试剂盒 ELISA Kit for Glycoprotein Ib Alpha Polypeptide, Platelet (GP1Ba) 

HZM427Hu 人Ras相关C3肉毒菌毒素底物1(Rac1)ELISA试剂盒 ELISA Kit for Ras Related C3 Botulinum Toxin Substrate 1 (Rac1) 

HZE320Hu 人Ras同源基因家族成员A(RHOA)ELISA试剂盒 ELISA Kit for Ras Homolog Gene Family, Member A (RHOA) 

HZE614Hu 人细胞分裂周期因子42(CDC42)ELISA试剂盒 ELISA Kit for Cell Division Cycle Protein 42 (CDC42) 

HZH911Hu 人肝细胞生长因子激活因子(HGFAC)ELISA试剂盒 ELISA Kit for Hepatocyte Growth Factor Activator (HGFAC) 

HZE879Hu 人分拣连接蛋白9(SNX9)ELISA试剂盒 ELISA Kit for Sorting Nexin 9 (SNX9) 

HZD762Hu 人犬尿氨酸酶(KYNU)ELISA试剂盒 ELISA Kit for Kynureninase (KYNU)