细胞转录因子ELK1抗体

英文名称    ELK1    

中文名称    细胞转录因子ELK1抗体    

别    名    ELK 1; ELK1 member of ETS oncogene family; ELK1 protein; ELK2 member of ETS oncogene family; ETS domain containing protein Elk 1; ETS domain containing protein Elk1; ETS domain protein Elk1; Oncogene Elk1; ETS domain-containing protein Elk-1 isoform a; ETS domain-containing protein Elk-1; ETS-like gene 1; tyrosine kinase (ELK1) oncogene; ELK1_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 细胞转录因子ELK1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    47kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human ELK1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞转录因子ELK1抗体产品介绍    background:

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012].

Function:
Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.

Subunit:
Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9.

Subcellular Location:
Nucleus.

Tissue Specificity:
Lung and testis.

Post-translational modifications:
Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention. 
On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14.

Similarity:
Belongs to the ETS family. 
Contains 1 ETS DNA-binding domain.

Gene ID:
2002

Database links:

Entrez Gene: 2002 Human

Entrez Gene: 13712 Mouse

Entrez Gene: 314436 Rat

Omim: 311040 Human

SwissProt: P19419 Human

SwissProt: P41969 Mouse

Unigene: 181128 Human

Unigene: 405823 Mouse

Unigene: 30029 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

细胞转录因子ELK1抗体

hz-1099R Calpain 1  钙蛋白酶1抗体

hz-1599R Calpain 2  钙激活的中性蛋白酶2抗体

hz-0095R Calponin 1/COLP  钙调节蛋白-1抗体

hz-3458R Phospho-Troponin I(Ser23/24)  磷酸化钙调节蛋白-1抗体

hz-4190R SLC27A1  长链脂肪酸转运蛋白1抗体

hz-3666R Calmodulin/CaM I  钙调节素抗体（钙调蛋白/钙调素）

hz-0564R CaMK2a  钙/钙调素依赖蛋白激酶2α抗体

hz-1647R Phospho-CaMKII (Thr286)  磷酸化钙/钙调素依赖蛋白激酶2α抗体

hz-3081R phospho-CaMK2 alpha (Tyr231)  磷酸化钙/钙调素依赖蛋白激酶2α抗体

hz-5276R phospho-CaMK2 alpha (Thr305)  磷酸化钙/钙调素依赖蛋白激酶2α抗体

hz-1809R Camk1g  钙/钙调蛋白依赖蛋白激酶IG抗体

hz-0541R CaMK2 beta/CaMK2 gamma  钙/钙调素依赖蛋白激酶2b/2γ抗体

hz-4260R XPB/ERCC3  DNA损伤修复酶ERCC3蛋白抗体

hz-5282R phospho-CAMK2G (Ter286)  磷酸化钙/钙调素依赖蛋白激酶CAMK2G抗体

hz-1306R CAP1/PARK7  CAP1抗体

hz-1616R CAP2  环化酶相关蛋白CAP-2抗体

hz-5161R CAPZA1  F肌动蛋白α1亚基抗体

hz-5128R CAPZA2/CapZ alpha 2  F肌动蛋白α2亚基抗体

hz-0799R CTn1/Troponin I/TNNC1  心肌肌钙蛋白抗体

hz-2534R CT-1/CTF1  心肌营养素1抗体

hz-1592R CA I/Carbonic anhydrase 1  碳酸酐酶1抗体

hz-1685R CTNNAL1  粘附分子相关蛋白a1抗体

hz-1709R CA II/Carbonic anhydrase 2  碳酸酐酶2抗体

hz-4029R CA IX  碳酸酐酶9抗体

hz-1078R CAS/CSE1  细胞凋亡敏感性基因抗体

hz-3496R Phospho-Cas (Tyr165)  磷酸化细胞凋亡敏感性基因

hz-0169R Caspase-1(actived P10)  天冬氨酸-胱氨酸特异性蛋白酶家族抗体

hz-5802R Caspase 2  半胱胺酸蛋白酶-2抗体

hz-0092R Caspase-10  半胱胺酸蛋白酶-10抗体

hz-1105R Caspase-12  半胱胺酸蛋白酶蛋白-12抗体

hz-0967R Caspase-12  半胱胺酸蛋白酶蛋白-12抗体

hz-0053R Caspase-13/4  半胱胺酸蛋白酶蛋白-13抗体

hz-0081R Caspase-3(Active)  活化半胱胺酸蛋白酶蛋白-3抗体

hz-0087R caspase-3 p12 subunit  活化半胱胺酸蛋白酶蛋白-3抗体

hz-2593R caspase-3 p11  半胱天冬酶-3酶原抗体