内皮抑素/内皮他丁抗体

英文名称    Endostatin    

中文名称    内皮抑素/内皮他丁抗体    

别    名    Collagen XV alpha 1; Alpha 1 collagen type 18 (XVIII)(COL18A1); Alpha 1 type XVIII collagen; COL18A1; Collagen alpha 1(XVIII) chain; Collagen type XVIII alpha 1; FLJ27325; KNO; MGC74745; COL18A1; COIA1_HUMAN; Antiangiogenic agent; COIA1_HUMAN; COL15A1; COL18A1; Collagen alpha 1(XV) chain; Collagen alpha-1(XV) chain; Collagen type XV proteoglycan; Collagen type XVIII alpha 1; Collagen XV, alpha 1 polypeptide; Collagen, type XV, alpha 1; Endostatin; Endostatin XV; FLJ34914; FLJ38566; KNO1; KS; Multi functional protein MFP; OTTHUMP00000021782; OTTHUMP00000115472; OTTHUMP00000115473.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  生长因子和激素      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 内皮抑素/内皮他丁抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    20kDa    

细胞定位    细胞外基质 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Endostatin    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

内皮抑素/内皮他丁抗体产品介绍    background:

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene.

Function:
COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. 
Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Present in multiple organs with highest levels in liver, lung and kidney.

Post-translational modifications:
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

DISEASE:
Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.

Similarity:
Belongs to the multiplexin collagen family.
Contains 1 FZ (frizzled) domain.
Contains 1 TSP N-terminal (TSPN) domain.

Gene ID:
1306

Database links:

Entrez Gene: 1306 Human

Entrez Gene: 80781 Human

Entrez Gene: 12819 Mouse

Entrez Gene: 12822 Mouse

Entrez Gene: 85251 Rat

Omim: 120328 Human

SwissProt: P39059 Human

SwissProt: P39060 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

内皮抑素/内皮他丁抗体

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