磷酸化双皮质素抗体

英文名称    Phospho-Doublecortin (Ser128)    

中文名称    磷酸化双皮质素抗体    

别    名    Doublecortin (phospho S128); p-Doublecortin (phospho S128); DBCN; DBCN; Dbct; Dbct; DC; DC; DCX; DCX; DCX_HUMAN; Doublecortex; Doublecortex; Doublin; FLJ51296; Lis X; Lis X; Lis-X; Lissencephalin X; Lissencephalin X; Lissencephalin-X; Lissencephaly X linked; Lissencephaly X linked; Lissencephaly X linked doublecortin; Lissencephaly X linked doublecortin; LISX; LISX; Neuronal migration protein doublecortin; OTTHUMP00000023859; OTTHUMP00000023860; OTTHUMP00000216315; OTTHUMP00000216316; SCLH; SCLH; XLIS; XLIS.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    神经生物学  生长因子和激素  内分泌病  细胞粘附分子  细胞类型标志物      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 磷酸化双皮质素抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    40kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human Doublecortin around the phosphorylation site of Ser128    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化双皮质素抗体产品介绍    background:

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Function:
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of a overlapping, but distinct, signaling pathways that promote neuronal migration.    

磷酸化双皮质素抗体

hz-8353R UBE2E2  泛素蛋白连接酶2E2抗体

hz-8354R UBE2D4  泛素蛋白连接酶D4抗体

hz-8355R UBE2D3  泛素蛋白连接酶D3抗体

hz-8356R UBE2D1  泛素蛋白连接酶D1抗体

hz-8357R UBE2C  泛素蛋白连接酶C抗体

hz-8358R KLHDC8A  KLHDC8A蛋白抗体

hz-8359R KLHDC9  KLHDC9蛋白抗体

hz-8360R LRRC2  LRRC2蛋白抗体

hz-8361R LRRC59  LRRC59蛋白抗体

hz-8362R LRRC41  LRRC41蛋白抗体

hz-8363R NIPA  间变性淋巴瘤激酶核相互作用伴侣蛋白抗体

hz-8364R phospho-NIPA(Ser354)  磷酸化间变性淋巴瘤激酶核相互作用伴侣蛋白抗体

hz-8365R RAB40B  RAS癌基因家族蛋白RAB40B抗体

hz-8366R RAB40A  RAS癌基因家族蛋白RAB40A抗体

hz-8367R RAB40C  RAS癌基因家族蛋白RAB40C抗体

hz-8368R EGR2  早期生长反应蛋白2抗体

hz-8369R Ube2L6  泛素载体蛋白L6抗体

hz-8370R Ube2H/UBCH2  泛素激活酶2H抗体

hz-8371R Ube2G1/UBC7  泛素蛋白连接酶G1抗体

hz-8372R UFC1  泛素结合酶UFC1抗体

hz-8373R UBCH6/UBE2E1  泛素蛋白连接酶E1抗体

hz-8374R UBC6e/UBE2J1  泛素结合酶E2J1抗体

hz-8375R UBE2A/UBE2B/RAD6  泛素结合酶E2蛋白A抗体

hz-8376R RNF160/ZNF294  环指蛋白160抗体

hz-8377R NFX1  核转录因子X盒结合蛋白1抗体

hz-8378R NCE2  泛素结合酶E2F抗体

hz-8379R HIP2  泛素蛋白连接酶E2抗体

hz-8380R UBE2O/E2 230K  泛素结合酶E2O抗体

hz-4169R PTK9/TWF1  蛋白酪氨酸激酶9抗体

hz-5613R phospho-PTK9/TWF1(Tyr321)  磷酸化蛋白酪氨酸激酶9抗体

hz-8381R UBE2J2  泛素蛋白连接酶J2抗体

hz-8382R UBE2M  泛素蛋白连接酶M抗体

hz-8383R UBE2Q1  泛素蛋白连接酶Q1抗体

hz-8384R UBE2U  泛素蛋白连接酶U抗体

hz-8385R UBE2W  泛素蛋白连接酶W抗体