英文名称 CRBN
中文名称 cereblon蛋白抗体
别 名 Cereblon; DKFZp781K0715; MGC27358; MRT2A; OTTHUMP00000209555; piL; Protein cereblon; Protein x 0001; 2610203G15Rik; 2900045O07Rik; AF229032; AW108261; CRBN_HUMAN.
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 神经生物学 细胞表面分子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 cereblon蛋白抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
细胞定位 细胞核 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRBN (210-288aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
cereblon蛋白抗体产品介绍 background:
CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. CRBN functions are thought to be related to energy metabolism, learning and memory. Localized to the cytoplasm, CRBN acts as a protease in mitochondria and is thought to regulate the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding CRBN belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the CRBN gene are associated with mild mental retardation.
Function:
Protein cereblon modulates cell surface expression of KCNT1 and may be involved in memory and learning. It is highly expressed in brain and defects in CRBN are the cause of non syndromic mental retardation autosomal recessive type 2A (MRT2A) [MIM:607417]. Although it contains a Lon domain also found in proteases of the peptidase S16 family, it does not contain the ATP binding and catalytic domains, suggesting that it has no protease activity.
cereblon蛋白抗体
hz-3092R Phospho-cdc2 (Tyr15) 磷酸化周期素依赖激酶2抗体
hz-3481R Phospho-cdc2 (Thr161) 磷酸化周期素依赖激酶2抗体
hz-5247R Phospho-cdc2 (Ser39) 磷酸化周期素依赖激酶2抗体
hz-2758R Cdc25A 细胞分裂周期蛋白25抗体
hz-3093R Phospho-cdc25A (Thr506) 磷酸化细胞分裂周期蛋白25抗体
hz-3094R Phospho-cdc25A (Ser76) 磷酸化细胞分裂周期蛋白25抗体
hz-3095R Phospho-cdc25A (Ser178) 磷酸化细胞分裂周期蛋白25抗体
hz-3096R Phospho-cdc25C (Ser216) 磷酸化细胞分裂周期蛋白25C抗体
hz-3482R Phospho-cdc25C (Thr48) 磷酸化细胞分裂周期蛋白25C抗体
hz-5242R Phospho-cdc25A (Ser124) 磷酸化细胞分裂周期蛋白25抗体
hz-5261R Phospho-cdc25A (Ser177) 磷酸化细胞分裂周期蛋白25抗体
hz-5262R Phospho-cdc25A (Ser292) 磷酸化细胞分裂周期蛋白25抗体
hz-2417R CD335/NKp46/NCR1 细胞毒性受体NK-p46抗体
hz-2420R CD336/NKp44/NCR2 细胞毒性受体NK-p44抗体
hz-2418R CD337/NKp30/NCR3 细胞毒性受体NK-p30抗体
hz-2466R CD328/Siglec-7 唾液酸结合性免疫球蛋白样凝集素7抗体
hz-4094R Cdc25B 细胞分裂周期蛋白25B抗体
hz-2705R CD329/SIGLEC8 CD329抗体
hz-5243R phospho-Cdc25B (Ser323) 磷酸化细胞分裂周期蛋白25B抗体
hz-5244R phospho-Cdc25B (Ser186) 磷酸化细胞分裂周期蛋白25B抗体
hz-2681R KLRF1/NKp80 细胞毒性受体NK-p80抗体
hz-5245R phospho-Cdc25B (Ser353) 磷酸化细胞分裂周期蛋白25B抗体
hz-2706R SIGLEC10/SLG2 唾液酸结合性免疫球蛋白样凝集素抗体
hz-1390R Cdc6 细胞分裂周期蛋白6抗体
hz-1448R Jagged1/CD339 Jagged1/CD339抗体
hz-5148R Cdc7 细胞分裂周期蛋白7抗体
hz-4244R Jagged 2 Notch配体Jagged 2蛋白抗体
hz-3525R SIGLEC14 唾液酸结合性免疫球蛋白样凝集素14抗体
hz-5246R phospho-Cdc6 (Ser54) 磷酸化细胞分裂周期蛋白6抗体
hz-2707R SIGLEC11 唾液酸结合性免疫球蛋白样凝集素11抗体
hz-1392R CDC34/UBC3 细胞周期调控因子34
hz-4295R CDC40 细胞分裂周期同源蛋白40抗体
hz-3813R CDC34B/UBC3B 泛素载体蛋白R2抗体
hz-5113R CDCA4 细胞分裂周期相关蛋白4抗体
企业名称
上海沪震生物科技有限公司
企业信息已认证
企业类型
信用代码
310112001371133
成立日期
2014-05-08
注册资本
1000
经营范围
上海沪震生物科技有限公司
公司地址
上海市杨浦区密云路1018号复旦科技园808室
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