细胞周期调控因子14A抗体

英文名称    Cdc14A    

中文名称    细胞周期调控因子14A抗体    

别    名    CDC 10; Cdc 14; Cdc 14A; Cdc 14A1; Cdc 14A2; CDC10; Cdc14; CDC14 cell division cycle 14 homolog A; CDC14 homolog A; Cdc14A1; Cdc14A2; Cell division cycle 14 homolog A; Dual specificity protein phosphatase CDC 14A; Dual specificity protein phosphatase CDC14A; hCDC14; CC14A_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  信号转导  细胞周期蛋白  激酶和磷酸酶  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 细胞周期调控因子14A抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    67kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Cdc14A    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞周期调控因子14A抗体产品介绍    background:

In budding yeast, the Cdc14a phosphatase activates mitotic exit by dephosphorylation of specific cyclin-dependent kinase (Cdk) substrates and seems to be regulated by sequestration in the nucleolus until its release during mitosis. Human Cdc14a phosphatase is highly similar to Saccharomyces cerevisiae Cdc14 and is a member of the dual specificity protein Tyrosine phosphatase family. It interacts with and dephosphorylates tumor suppressor protein p53 and may regulate the function of p53. In addition, Cdc14a dephosphorylates hCdh1 and activates APCCdh1. Cdc14a phosphatase plays a role in the regulation of the centrosome cycle, mitosis and cytokinesis, thereby influencing chromosome partitioning and genomic stability in human cells. Deregulated human Cdc14a phosphatase disrupts centrosome separation and chromosome segregation.

Function:
Overproduction of hCdc14A leads to progressive cell death, accompanied by accumulation of pre-G1 DNA fragments and gradual elimination of cells at the G2/M transition. In 50% of the mitotic cells, multipolar mitotic spindles and misaggregated chromosomes are found. hCdc14A localizes to the centrosomes at the cell-cycle interphase stage. When the cell enters mitosis, this localization disappears suggesting that hCdc14A dissociates from the centrosomes at the G2/M transition. hCdc14A localizes to interphase centrosomes, but not to mitotic centrosomes, while hCdc14B localizes to the interphase nucleolus. Thus each isoform regulates separate cell cycle events. Cdc14A may affect cell cycle progression by its ability to dephosphorylate p53 at Ser315. This phosphatase activity is mediated by the interaction between the N-terminus of hCdc14A and the C-terminus of p53.    

细胞周期调控因子14A抗体

hz-5186R phospho-APP/ABPP(Thr743)  磷酸化APP淀粉样肽前体蛋白抗体

hz-9829R C3orf37  3号染色体开放阅读框37抗体

hz-9830R C3orf39  3号染色体开放阅读框39抗体

hz-1632R APPL1  衔接因子蛋白含pH域磷酸酪氨酸结合域和亮氨酸拉链蛋白1抗体

hz-9831R C3orf49  3号染色体开放阅读框49抗体

hz-9832R C3orf54  3号染色体开放阅读框54抗体

hz-9833R C3orf59/MB21D2  3号染色体开放阅读框59抗体

hz-9836R HLC8/Lung cancer related protein 8  肺癌相关蛋白8抗体

hz-9838R C17orf59  17号染色体开放阅读框59抗体

hz-9837R C17orf104  17号染色体开放阅读框104抗体

hz-9839R C17ORF39  17号染色体开放阅读框39抗体

hz-5189R phospho-APP/ABPP(Ser198)  磷酸化APP淀粉样肽前体蛋白抗体

hz-9840R RNF213  环指蛋白213

hz-9841R HIV1 p55 + p17  艾滋病病毒p55抗体

hz-9842R phospho-LEF1(Ser42)  磷酸化淋巴增强因子-1抗体

hz-9843R HCF2/Heparin Cofactor II  肝素辅助因子II抗体

hz-9844R PLGLB2  纤溶酶相关蛋白B2抗体

hz-9845R GDN/SERPINE2  胶质源性连接蛋白抗体

hz-9846R Streptokinase  链激酶抗体

hz-9847R AE2/SLC4A2  阴离子交换蛋白2抗体

hz-9848R Aconitase 1/IRP-1  铁调节蛋白1抗体

hz-9849R BAALC  脑和急性白血病胞浆蛋白抗体

hz-9850R BST2/CD317  骨髓基质干细胞抗原2抗体

hz-1506R AQP1/CHIP  水通道蛋白1抗体

hz-9851R CLNS1A/pICln  氯离子通道调节蛋白1A抗体

hz-9852R TFCP2C  转录因子CP2抗体

hz-9853R CSEN/KCNIP3/DREAM  钾通道相互作用蛋白3抗体

hz-9854R HSPβ7/cvHSP  热休克蛋白β7抗体

hz-9855R SLN/Sarcolipin  肌脂蛋白抗体

hz-9856R HCN3  钾/钠超极化激活环核苷酸门控通道蛋白3抗体

hz-9857R KCNG2  心脏钾离子通道蛋白亚基2抗体

hz-9858R HCN2  钾/钠超极化激活环核苷酸门控通道蛋白2抗体

hz-9859R CCAP/Cardioactive Peptide  心动加速蛋白多肽抗体