磷酸化细胞分裂相关蛋白CSTF64抗体

英文名称    phospho-CstF64(Ser498)    

中文名称    磷酸化细胞分裂相关蛋白CSTF64抗体    

别    名    p-CstF-64 (Ser498); p-CstF-64 (S498); CstF64 (phospho-Ser498); CstF64 (phospho-S498); CSTF2T; CF1 64 kDa subunit, tau variant; Cleavage stimulation factor 64 kDa subunit, tau variant; CSTF 64 kDa subunit, tau variant; KIAA0689; TauCstF64; CSTF2_HUMAN.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  细胞生物  细胞分化  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）磷酸化细胞分裂相关蛋白CSTF64抗体 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    61kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthesised phosphopeptide derived from human CstF64 around the phosphorylation site of Ser498    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化细胞分裂相关蛋白CSTF64抗体产品介绍    background:

Polyadenylation of mRNA precursors is a two-step reaction that requires multiple protein factors. The first step, endonucleolytic cleavage of polyadenylation substrates, requires CstF (cleavage stimulation factor), a heterotrimer that is composed of three distinct subunits. CstF-64 contains an RNA binding domain and is responsible for the RNA binding activity of CstF. CstF-64 is expressed in all somatic cells and in pre- and postmeiotic, but not meiotic, germ cells. However, a large variant of CstF-64, called t CstF-64, is abundantly expressed in meiotic and postmeiotic cells in the testis and to a lesser extent in the brain, and promotes the germ cell pattern of polyadenylation. The gene encoding CstF-64 (designated CSTF2) maps to the X chromosome, whereas t CstF-64 is encoded by an autosomal gene. The increase in CstF-64 concentration during B cell activation switches IgM heavy chain mRNA expression from membrane-bound to secreted forms, suggesting that CstF-64 plays a key role in regulating IgM heavy chain expression during B cell differentiation.

Function:
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). 
磷酸化细胞分裂相关蛋白CSTF64抗体  

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hz-2985R ADM2  中介素抗体

hz-2986R CATSPER  阳离子通道精子相关蛋白1抗体

hz-2987R Vitamin D Receptor/VDR  维生素D3受体抗体

hz-2988R Mitofusin 2/MFN2  线粒体融合蛋白Mfn2抗体

hz-1230R ABL2  ABL2蛋白抗体

hz-1961R ABI1  ABI1/SSH3BP1蛋白抗体

hz-4048R ACADS  酰基辅酶A脱氢酶短链抗体

hz-2410R ABP/SHBG  雄激素结合蛋白抗体

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hz-5015R ACADL  酰基辅酶A脱氢酶长链抗体

hz-5018R ACADVL  酰基辅酶A脱氢酶很长链抗体

hz-5019R ACAT1  胆固醇酰基转移酶1抗体

hz-5020R SOAT2/ACAT2  胆固醇酰基转移酶2抗体

hz-2390R Aconitase 2/ACO2  铁调节蛋白2抗体

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hz-3920R ADCY2  腺苷酸环化酶2抗体

hz-4021R ADCY3  腺苷酸环化酶3抗体

hz-3921R ADCY4  腺苷酸环化酶4抗体

hz-3922R ADCY5  腺苷酸环化酶5抗体

hz-3923R ADCY6  腺苷酸环化酶6抗体

hz-3924R ADCY7  腺苷酸环化酶7抗体

hz-3925R ADCY8  腺苷酸环化酶8抗体

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hz-3916R ADCY10  腺苷酸环化酶10抗体

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