维甲酸调节核基质相关蛋白抗体

英文名称    CDT2    

中文名称    维甲酸调节核基质相关蛋白抗体    

别    名    Lethal(2) denticleless protein homolog; CDW1; CDW1; DCAF2; DDB1 and CUL4 associated factor 2; Ddb1- and Cul4-associated factor 2; Denticleless homolog; Denticleless homolog (Drosophila); Denticleless protein homolog; Dtl; DTL_HUMAN; L2DTL; Lethal(2) denticleless protein homolog; RA regulated nuclear matrix associated protein; RAMP; Retinoic acid regulated nuclear matrix associated protein; Retinoic acid-regulated nuclear matrix-associated protein.    

说 明 书    0.2ml      

研究领域    细胞生物  细胞周期蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 维甲酸调节核基质相关蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    80kDa    

细胞定位    细胞核 细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RAMP/CDT2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

维甲酸调节核基质相关蛋白抗体产品介绍    background:

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Tissue specificity: Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.    

维甲酸调节核基质相关蛋白抗体

hz-1491P ShK(Stichodactyla helianthus Neurotoxin)-(Arg22)  海葵神经毒素（35肽）

hz-1492P ShK(Stichodactyla helianthus Neurotoxin)-(Dap22)  海葵神经毒素（35肽）

hz-1320P ShK(Stichodactyla helianthus Neurotoxin)-(Gln9)  海葵神经毒素（35肽）

hz-1321P ShK(Stichodactyla helianthus Neurotoxin)-(Gln11)  海葵神经毒素（35肽）

hz-2000Pr rHBcAg  重组乙肝病毒核心抗原

hz-1662P rHBeAg(Hepatitis B Virus E Antigen protein)  重组乙肝病毒e抗原

hz-2005P rDen(rh-Dengue Virus)  多价重组人登革热病毒诊断抗原

hz-2298P rDen-2(rh-Dengue Virus)  重组人登革热病毒2型诊断抗原

hz-0994P rSLT/SLT-IIe(O139)  重组猪水肿素蛋白

Y-0184 ADM (Adrenomedullin)(22-52)  肾上腺髓质素（22-52）

Y-0183 ADM (Adrenomedullin)(22-42)  肾上腺髓质素（22-42）

hz-0096P AAT(Alpha-1Anti-tiypsin)  α-1抗胰蛋白酶(抗原）

hz-2062P FPP(Fertilization Promoting Peptide)  受精促进肽

hz-0203P ACEI (Angiotensin I Converting Enzyme Inhibitor )  血管紧张素1转换酶抑制剂(抗原）

hz-0120P Acinus peptide  ACINUS 多肽抗原

hz-0706PB T4-BSA  甲状腺素T4偶联牛血清白蛋白

hz-0774P mouse IgA  小鼠IgA

hz-0004P ACTH (Adrenorticotrophin hormons)(7-23)  促肾上腺皮质激素（7-23）(抗原）

hz-0862P Insulin (from porcine pancreas)  胰岛素

hz-0189P Actin Alpha /Alpha-SMA (Actin alpha , smooth muscle aorta)  肌动蛋白(抗原）

hz-2372P rHBsAg   重组乙肝病毒表面抗原

hz-0322P AEBP1 (Adipocyte enhance binding protein 1)  脂肪细胞增强结合蛋白1

hz-0904P-HRP Melamine/HRP  辣根过氧化物酶标记三聚氰胺

hz-1034P SP-B peptide  肺表面活性蛋白B抗原

hz-1037P DCP peptide  异常凝血酶原/脱-γ-羧基凝血酶原抗原

hz-0397P MMP-9(matrix metalloproteinase 9)  基质金属蛋白酶-9(抗原)

hz-0177P AGER(Advanced glycosylation end product-specific receptor)  晚期糖基化终末产物特异性受体(抗原）

hz-0237P 14-3-3 protein  14-3-3 蛋白（多肽抗原）

hz-2017P 14-3-3 family protein(Malus domestica (Apple) (Malus sylvestris))  植物14-3-3蛋白抗原

hz-1154P FRA1/FOSL1 peptide   FRA-1多肽蛋白

hz-0037P AIF　(Apoptosis-Inducing Factor)  调亡诱导因子(多肽片断抗原）

hz-0299P Adenylate Kinase 1 (AK-1)  腺苷酸激酶-1

hz-0115P Akt/PKB  蛋白激酶B（抗原）