肿瘤/睾丸抗原27抗体（高迁移率族蛋白）

英文名称    CT27    

中文名称    肿瘤/睾丸抗原27抗体（高迁移率族蛋白）    

别    名    BORIS like protein; Brother of the regulator of imprinted sites; Cancer/testis antigen 27; CCCTC binding factor (zinc finger protein) like; CCCTC-binding factor; CT27; CTCF paralog; CTCF T; CTCF-like protein; CTCFL; CTCFL_HUMAN; HMG 1L1; HMGB1L1; Putative high mobility group protein 1 like 1; Putative high mobility group protein B1 like 1; Transcriptional repressor CTCFL; Zinc finger protein CTCF-T.    

说 明 书    0.2ml      

研究领域    肿瘤  免疫学  染色质和核信号  信号转导  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 肿瘤/睾丸抗原27抗体（高迁移率族蛋白）（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    72kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human BORIS/CT27    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

肿瘤/睾丸抗原27抗体（高迁移率族蛋白）产品介绍    background:

Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.

Function:
Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.    

肿瘤/睾丸抗原27抗体（高迁移率族蛋白）

hz-6632R NESG1/CCDC19  鼻咽上皮细胞特异性蛋白1抗体

hz-6633R FOXL2  小睑裂综合征蛋白BPES抗体

hz-6634R XPC  DNA补充修复XPC细胞蛋白抗体

hz-6636R EPHA10  酪氨酸蛋白激酶受体A10抗体

hz-6637R TP53I8/EI24  肿瘤蛋白p53诱导蛋白8

hz-6638R EVC2  膜蛋白EVC2抗体

hz-6639R BMPR1B  骨形态发生蛋白受体1B抗体

hz-6640R Vinculin  粘着斑蛋白抗体

hz-6641R DNA Ligase 1  DNA连接酶1抗体

hz-6642R FOXC1/FREAC3  叉头相关转录因子3抗体

hz-6643R SCYL1BP1  SCYL结合蛋白1抗体

hz-6644R Gephyrin  桥尾蛋白抗体

hz-6645R WNT7A  原癌基因wnt7a蛋白抗体

hz-6646R BLK/MODY11  B淋巴细胞酪氨酸激酶抗体

hz-6647R COG1  COG1蛋白抗体

hz-6648R BAP31  BAP31蛋白抗体

hz-6649R ADORA1/Adenosine A1 Receptor  腺苷A1受体抗体

hz-6650R SDHB  铬细胞瘤患者抑癌基因SDHB抗体

hz-6651R ApoER2  载脂蛋白E2受体抗体

hz-6652R CRMP1  二氢嘧啶酶相关蛋白1抗体

hz-6653R IFI78/MX1  干扰素诱导蛋白P78抗体

hz-6654R ADA/Adenosine deaminase  腺苷脱氨酶抗体

hz-6655R Cryopyrin/CIAS1/NALP3  细胞凋亡诱导蛋白NALP3抗体

hz-6656R Cyclin B2  周期素B2抗体

hz-6657R PRX/periaxin  轴周蛋白PRX抗体

hz-6658R Calumenin/CALU  钙腔蛋白

hz-6659R CD98  CD98重链抗原抗体

hz-6660R hzerin  hzerin蛋白抗体

hz-6661R AQP0/MIP26  水通道蛋白0抗体

hz-6662R TYK2  非受体酪氨酸蛋白激酶2抗体

hz-6663R HRH1  组胺受体H1抗体

hz-6664R HRH2  组胺受体H2抗体

hz-6665R phospho-HRH1(Ser398)  磷酸化组胺受体H1抗体

hz-6666R HOXA11  同源盒蛋白HOXA11抗体

hz-6667R HOXA9  同源盒蛋白HOXA9抗体