肿瘤易感候选基因3抗体

英文名称    CASC3    

中文名称    肿瘤易感候选基因3抗体    

别    名    Barentsz protein; Btz; Cancer susceptibility candidate gene 3 protein; Metastatic lymph node protein 51; MLN 51 protein; MLN51; Protein barentsz; Protein CASC3; Protein MLN 51; MLN51; CASC3_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  信号转导      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 肿瘤易感候选基因3抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    76kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CASC3/MLN51    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

肿瘤易感候选基因3抗体产品介绍    background:

The multiprotein exon junction complex (EJC) is deposited on mRNAs upstream of exon–exon junctions as a consequence of pre-mRNA splicing. In mammalian cells, this complex serves as a key modulator of spliced mRNA metabolism. MLN51 is a nucleocytoplasmic shuttling protein that is overexpressed in breast cancer. The function of MLN51 in mammals remains elusive. Its fly homolog, named barentsz, as well as the proteins mago nashi and tsunagi have been shown to be required for proper oskar mRNA localization to the posterior pole of the oocyte. Magoh and Y14, the human homologs of mago nashi and tsunagi, are core components of the exon junction complex (EJC). The EJC is assembled on spliced mRNAs and plays important roles in post-splicing events including mRNA export, nonsense-mediated mRNA decay, and translation. Human MLN51 is an RNA-binding protein present in ribonucleo-protein complexes.

Function:
Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons (By similarity). May play a role in mRNA transport (By similarity). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer.    

肿瘤易感候选基因3抗体

hz-4182R RPA32/RPA2  复制因子A蛋白2

hz-5693R phospho-RPA32/RPA2(Thr21)  磷酸化复制因子A蛋白2抗体

hz-4186R RAC1/MIG5  细胞迁移诱导因子5抗体

hz-5698R phospho-RAC1(Ser71)  磷酸化细胞迁移诱导因子5抗体

hz-6153R RAC2  G蛋白P21 RAC2抗体

hz-6154R RAC1+RAC2  GTP结合蛋白RAC1+RAC2抗体

hz-4222R PSME3/PA28 gamma  蛋白酶体激活因子PA28γ抗体

hz-4125R Pancreatic Lipase  胰脂肪酶抗体

hz-4183R RPH3AL  Ras相关GTP结合蛋白抗体

hz-5695R phospho-RPH3AL(Ser234)  磷酸化Ras相关GTP结合蛋白抗体

hz-4196R Prostaglandin E Receptor EP2  前列腺素E2受体2抗体

hz-2251R A Raf/ARAF  A-Raf抗体

hz-3005R phospho-A Raf(Ser214)  磷酸化A-Raf抗体

hz-3371R Phospho-A Raf(Ser299)  磷酸化A-Raf抗体

hz-3421R Phospho-A Raf(Tyr301/302)  磷酸化A-Raf抗体

hz-1089R B-Raf  B Raf抗体

hz-1703R c-Raf/Raf1  癌基因c-Raf抗体

hz-3013R phospho-B-Raf (Ser365)  磷酸化B-Raf抗体

hz-3373R phospho-B-Raf (Ser444)  磷酸化B-Raf抗体

hz-3374R phospho-B-Raf (Ser602)  磷酸化B-Raf抗体

hz-5232R phospho-B-Raf (Ser446)  磷酸化B-Raf抗体

hz-5233R phospho-B-Raf (Thr597)  磷酸化B-Raf抗体

hz-5224R phospho-B-Raf (Thr401)  磷酸化B-Raf抗体

hz-0802R BRCA1/BAP1  乳腺癌易感基因1抗体

hz-3051R Phospho-BAP1(Ser592)  磷酸化乳腺癌易感基因1抗体(人)

hz-3014R Phospho-BRCA1(Ser1524)  磷酸化乳腺癌易感基因1抗体

hz-5710R BRCC4/BRCC45  乳腺癌易感基因复合蛋白4抗体

hz-5221R Phospho-BRCA1(Ser1189)  磷酸化乳腺癌易感基因1抗体

hz-5222R Phospho-BRCA1(Ser1423)  磷酸化乳腺癌易感基因1抗体

hz-0803R BRCA1/BAP1  乳腺癌易感基因1抗体

hz-1210R BRCA2  乳腺癌易感基因2抗体

hz-0489R BrdU  溴脱氧尿苷抗体

hzm-0917M BrdU(A7)  溴脱氧尿苷单克隆抗体

hz-0917R BrdU  溴脱氧尿苷抗体

hz-3669R BRN3A  转录因子Brn3蛋白抗体Brn3α

hz-3668R Brs3/Bombesin Receptor 3  蛙皮素受体3抗体