磷酸化α-连环蛋白抗体

英文名称    phospho-CTNNA1 (Ser641)    

中文名称    磷酸化α-连环蛋白抗体    

别    名    p-CTNNA1 (Ser641); CTNNA1 (phospho-Ser641); CTNNA1 (phospho-S641); alpha 1 Catenin (phospho S641); alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadherin associated protein; CAP 102; CAP102; Catenin (cadherin associated protein) alpha 1 102kDa; Catenin alpha 1; CTNNA 1; CTNNA1; Alpha-cats; FLJ36832; NY REN 13 antigen; CTNA1_HUMAN.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  细胞生物  免疫学  信号转导  干细胞  细胞粘附分子  细胞骨架      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500磷酸化α-连环蛋白抗体 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    100kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human CTNNA1 around the phosphorylation site of Ser641 [DD(p-S)DF]    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化α-连环蛋白抗体产品介绍    background:

The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.

Function:
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.    

磷酸化α-连环蛋白抗体

hz-0092R Caspase-10  半胱胺酸蛋白酶-10抗体

hz-1105R Caspase-12  半胱胺酸蛋白酶蛋白-12抗体

hz-0967R Caspase-12  半胱胺酸蛋白酶蛋白-12抗体

hz-0053R Caspase-13/4  半胱胺酸蛋白酶蛋白-13抗体

hz-0081R Caspase-3(Active)  活化半胱胺酸蛋白酶蛋白-3抗体

hz-0087R caspase-3 p12 subunit  活化半胱胺酸蛋白酶蛋白-3抗体

hz-2593R caspase-3 p11  半胱天冬酶-3酶原抗体

hz-0082R Caspase 4  半胱胺酸蛋白酶蛋白-4抗体

hz-0151R Caspase-6 (CT)  半胱胺酸蛋白酶蛋白-6抗体（C端）

hz-0084R Caspase-6 (NT)  半胱胺酸蛋白酶蛋白-6抗体(N端)

hz-0084M Caspase-6 (NT)  半胱胺酸蛋白酶蛋白-6抗体(N端)

hz-5240R phospho-Caspase 6 (Ser257)  磷酸化半胱胺酸蛋白酶蛋白6抗体

hz-3665R Caspase-7  半胱胺酸蛋白酶蛋白-7抗体

hz-2322R Caspase-7  半胱胺酸蛋白酶蛋白-7抗体

hz-0052R Caspase 8  半胱氨酸蛋白酶8抗体

hz-0049R Caspase-9  白介素1-β转化酶样凋亡蛋白酶6抗体

hz-0050R Caspase-9  白介素1-β转化酶样凋亡蛋白酶6抗体

hz-3082R Phospho-Caspase-9 (Thr125)  磷酸化半胱氨酸蛋白酶9抗体

hz-3083R Phospho-Caspase-9 (Tyr153)  磷酸化半胱氨酸蛋白酶9抗体

hz-5241R Phospho-Caspase-9 (Ser196)  磷酸化半胱氨酸蛋白酶9抗体

hz-1453R Caveolin-1  细胞质膜微囊蛋白-1抗体

hz-3480R Phospho-Caveolin-1 (Tyr14)  磷酸化细胞质膜微囊蛋白-1抗体

hz-3610R Caveolin-3  细胞质膜微囊蛋白-3抗体

hz-1594R Alpha-Catenin/CTNNA1  α-连环蛋白抗体（钙粘蛋白相关蛋白）

hz-5280R phospho-CTNNA1 (Ser641)  磷酸化α-连环蛋白抗体

hz-1165R β-catenin  β-连环蛋白/β-连环素/β链接素抗体

hz-2063R phospho-β catenin(Tyr142)  磷酸化β 连环素蛋白抗体

hz-3084R Phospho-Beta-Catenin(Ser33/37)  磷酸化β 连环素蛋白抗体

hz-3085R Phospho-Beta-Catenin(Ser45)  磷酸化β 连环素蛋白抗体

hz-3086R Phospho-Beta-Catenin (Ser552)  磷酸化β 连环素蛋白抗体