英文名称 phospho-CDKN1A (Thr57)
中文名称 磷酸化p21蛋白抗体
别 名 Activating Fragment 1; CAP20; Cation chloride cotransporter-interacting protein 1; CDK Interacting Protein 1; CDK-interacting protein 1; CDKI; CDKN 1; CDKN1; CDKN1A; CIP1; Cyclin Dependent Kinase Inhibitor 1A; Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1A (P21); Cyclin-dependent kinase inhibitor 1A (p21, Cip1); DNA Synthesis Inhibitor; MDA 6; MDA-6; MDA6; Melanoma Differentiation Associated Protein 6; Melanoma differentiation-associated protein 6; Melanoma differentiation-associated protein; p21; P21 protein; p21CIP1; p21WAF; PIC1; SDI1; SLC12A9; WAF1; Wildtype p53 Activating Fragment 1; Wildtype p53-activated fragment 1.
说 明 书 0.1ml
产品类型 磷酸化抗体
研究领域 肿瘤 免疫学 信号转导 细胞周期蛋白
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 磷酸化p21蛋白抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human CDKN1A around the phosphorylation site of Thr57 [TE(p-T)PL]
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
磷酸化p21蛋白抗体产品介绍 background:
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
Function:
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
磷酸化p21蛋白抗体
hz-11041R Bestrophin 2 卵黄状黄斑病蛋白2抗体
hz-11042R Bestrophin 3 卵黄状黄斑病蛋白3抗体
hz-11043R Bestrophin 4 卵黄状黄斑病蛋白4抗体
hz-11045R C1QL1 补体组分1q子成分样蛋白1抗体
hz-11046R CHL1/CALL 神经细胞粘附分子CALL抗体
hz-11047R COL6A5/Collagen VI alpha 5 6型胶原蛋白α5抗体
hz-11049R CPA6 胰羧肽酶A6抗体
hz-11050R GJC2/Connexin 47 间隙连接蛋白47抗体
hz-4215R Sin3b 转录抑制蛋白Sin3b抗体
hz-11051R HAPLN2 透明质酸及粘蛋白2抗体
hz-11052R HAS3 透明质酸合成酶3抗体
hz-11053R KAL1 卡尔曼综合征基因1抗体
hz-11054R Keratocan 细胞角膜蛋白多糖抗体
hz-11055R Laminin alpha 4 层粘蛋白α4抗体(Lamininα4)
hz-11056R Laminin alpha 4 层粘蛋白α4抗体(Lamininα4)
hz-11057R Ligamentum Nuchae Elastin 项韧带弹性蛋白抗体
hz-11058R APBA3/Mint3/X11gamma β淀粉样前体蛋白结合蛋白3抗体
hz-11059R NTN3/Netrin-3 轴突生长诱导因子3抗体
hz-4216R Sphingomyelin Synthase 1 鞘磷脂合成酶1抗体
hz-11060R OTOA/DFNB22 耳聋、常染色体隐性遗传22抗体
hz-11061R OLFM3/Optimedin 嗅球蛋白3抗体
hz-4217R SMS2/Sphingomyelin Synthase 2 鞘磷脂合成酶2抗体
hz-11062R PSCDBP/CYTIP 胞粘蛋白结合调节蛋白抗体
hz-11063R Plakophilin 2 桥粒斑菲素蛋白2抗体
hz-11064R SPON2/M spondin/Mindin 细胞外基质底物反应蛋白2抗体
hz-11065R SNTG2/Syntrophin 5 肌蛋白结合蛋白γ2抗体
hz-11066R DOK6 胞浆接头蛋白Dok6抗体
hz-11067R TECTB 遗传性耳聋β-tectorin抗体
hz-11068R TNR/Tenascin-R 腱糖蛋白R抗体
hz-11069R procollagen type IIA Ⅱ型胶原α1抗体
hz-11070R AMIGO1 粘附分子IgG样结构域蛋白1抗体
hz-11071R ANTXR2 炭疽毒素受体2抗体
hz-11072R ASTN2 星形肌动蛋白抗体
hz-11073R CDH18 钙粘附分子18抗体
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