磷酸化p21蛋白抗体

英文名称    phospho-CDKN1A (Thr57)    

中文名称    磷酸化p21蛋白抗体    

别    名    Activating Fragment 1; CAP20; Cation chloride cotransporter-interacting protein 1; CDK Interacting Protein 1; CDK-interacting protein 1; CDKI; CDKN 1; CDKN1; CDKN1A; CIP1; Cyclin Dependent Kinase Inhibitor 1A; Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1A (P21); Cyclin-dependent kinase inhibitor 1A (p21, Cip1); DNA Synthesis Inhibitor; MDA 6; MDA-6; MDA6; Melanoma Differentiation Associated Protein 6; Melanoma differentiation-associated protein 6; Melanoma differentiation-associated protein; p21; P21 protein; p21CIP1; p21WAF; PIC1; SDI1; SLC12A9; WAF1; Wildtype p53 Activating Fragment 1; Wildtype p53-activated fragment 1.    

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  免疫学  信号转导  细胞周期蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 磷酸化p21蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    18kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human CDKN1A around the phosphorylation site of Thr57 [TE(p-T)PL]    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化p21蛋白抗体产品介绍    background:

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.

Function:
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.    

磷酸化p21蛋白抗体

hz-11041R Bestrophin 2  卵黄状黄斑病蛋白2抗体

hz-11042R Bestrophin 3  卵黄状黄斑病蛋白3抗体

hz-11043R Bestrophin 4  卵黄状黄斑病蛋白4抗体

hz-11045R C1QL1  补体组分1q子成分样蛋白1抗体

hz-11046R CHL1/CALL  神经细胞粘附分子CALL抗体

hz-11047R COL6A5/Collagen VI alpha 5  6型胶原蛋白α5抗体

hz-11049R CPA6  胰羧肽酶A6抗体

hz-11050R GJC2/Connexin 47  间隙连接蛋白47抗体

hz-4215R Sin3b  转录抑制蛋白Sin3b抗体

hz-11051R HAPLN2  透明质酸及粘蛋白2抗体

hz-11052R HAS3  透明质酸合成酶3抗体

hz-11053R KAL1  卡尔曼综合征基因1抗体

hz-11054R Keratocan  细胞角膜蛋白多糖抗体

hz-11055R Laminin alpha 4  层粘蛋白α4抗体(Lamininα4)

hz-11056R Laminin alpha 4  层粘蛋白α4抗体(Lamininα4)

hz-11057R Ligamentum Nuchae Elastin  项韧带弹性蛋白抗体

hz-11058R APBA3/Mint3/X11gamma  β淀粉样前体蛋白结合蛋白3抗体

hz-11059R NTN3/Netrin-3  轴突生长诱导因子3抗体

hz-4216R Sphingomyelin Synthase 1  鞘磷脂合成酶1抗体

hz-11060R OTOA/DFNB22  耳聋、常染色体隐性遗传22抗体

hz-11061R OLFM3/Optimedin  嗅球蛋白3抗体

hz-4217R SMS2/Sphingomyelin Synthase 2  鞘磷脂合成酶2抗体

hz-11062R PSCDBP/CYTIP  胞粘蛋白结合调节蛋白抗体

hz-11063R Plakophilin 2  桥粒斑菲素蛋白2抗体

hz-11064R SPON2/M spondin/Mindin  细胞外基质底物反应蛋白2抗体

hz-11065R SNTG2/Syntrophin 5  肌蛋白结合蛋白γ2抗体

hz-11066R DOK6  胞浆接头蛋白Dok6抗体

hz-11067R TECTB  遗传性耳聋β-tectorin抗体

hz-11068R TNR/Tenascin-R  腱糖蛋白R抗体

hz-11069R procollagen type IIA  Ⅱ型胶原α1抗体

hz-11070R AMIGO1  粘附分子IgG样结构域蛋白1抗体

hz-11071R ANTXR2  炭疽毒素受体2抗体

hz-11072R ASTN2  星形肌动蛋白抗体

hz-11073R CDH18  钙粘附分子18抗体